Dwight D Eisenhower Highway, I 99 $north; US 220 $north
192.6 mi3 hours 10 mins
| Head west on King Street | 0.4 mi | |
| Turn right onto North Patrick Street (US 1) | 0.8 mi | |
| Continue onto North Henry Street (US 1) | 0.2 mi | |
| Continue onto Richmond Highway (US 1) | 3.1 mi | |
| Keep left towards VA 110 North: Rosslyn | 2.5 mi | |
| Merge left onto Custis Memorial Parkway (I 66 W) | 700 feet | |
| Take the ramp towards US 29: Rosslyn | 0.2 mi | |
| Turn right onto North Lynn Street (US 29) | 100 feet | |
| Take the ramp on the left | 0.3 mi | |
| Merge right onto George Washington Memorial Parkway (GWMP) | 0.3 mi | |
| Keep right onto George Washington Memorial Parkway (GWMP) | 7.4 mi | |
| Keep right towards I 495 North: Maryland | 0.4 mi | |
| Merge left onto Capital Beltway (I 495 N) | 3.6 mi | |
| Keep left towards I 270: Rockville | 1.4 mi | |
| Continue onto I 270 Spur N | 0.9 mi | |
| Merge left onto I 270 N | 0.8 mi | |
| Keep right towards I 270 North | 28.3 mi | |
| Take the ramp towards I 70: Hagerstown | 0.4 mi | |
| Keep left towards I 70 West: Hagerstown | 0.4 mi | |
| Merge right onto I 70 | 76.1 mi | |
| Merge left onto Lincoln Highway (US 30) | 1,000 feet | |
| Turn right onto I 70 W | 1.6 mi | |
| Keep right towards I 70 West: Pittsburgh | 0.4 mi | |
| Merge left onto Pennsylvania Turnpike (I 70 W) | 15.5 mi | |
| Take the ramp towards Altoona | 0.3 mi | |
| Keep left towards Altoona | 100 feet | |
| Turn left onto North Richard Street (US 220 Business) | 0.3 mi | |
| Take the ramp on the left towards I 99: Cumberland | 0.2 mi | |
| Keep right towards I 99 North: Altoona | 0.3 mi | |
| Merge left onto I 99 N | 44.9 mi | |
| Take the ramp towards Tipton | 0.7 mi | |
| Keep right at the fork | 600 feet | |
| Go straight onto North Pleasant Valley Boulevard (US 220 Business) | 700 feet | |
| Continue onto Old Route 220 (US 220 Business) | 400 feet | |
| Turn left | 200 feet | |
| Turn left onto McFarland Road | 0.4 mi | |
| You have arrived at your destination, on the left |
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Alexandria, Virginia - Charlottsville, Pennsylvania