I 35 $south, I 49 $south; US 71 $south
747.6 mi12 hours 30 mins
| Head northwest on 220th Trail (IA 220) | 200 feet | |
| Make a sharp left onto W Avenue (US 151) | 4.9 mi | |
| Turn left onto U Avenue (US 151) | 5.5 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 80 | 238.6 mi | |
| Continue onto I 35 S | 34.5 mi | |
| Keep left onto Chicago-Kansas City Expressway (I 35 S) | 1.5 mi | |
| Take exit 12 towards I 435 South: Saint Louis | 0.7 mi | |
| Merge left onto I 435 | 9.6 mi | |
| Keep left onto Lamar Hunt Memorial Highway (I 435) | 8.9 mi | |
| Take exit 71 towards I 49 South: Joplin | 0.7 mi | |
| Keep left at the fork | 800 feet | |
| Keep left towards I 49 South: Joplin | 0.3 mi | |
| Merge left onto I 49 S | 24.7 mi | |
| Keep left onto I 49 S | 105.3 mi | |
| Take exit 53 towards I 49 Business: Webb City | 800 feet | |
| Turn right onto I 49 Business | 1.4 mi | |
| Keep left onto I 49 Business | 5.3 mi | |
| Keep left towards MO 249 South: Joplin | 6.2 mi | |
| Continue onto I 49 S | 122.0 mi | |
| Keep right towards I 40 West: Van Buren | 0.3 mi | |
| Merge left onto I 40 | 4.3 mi | |
| Take the ramp towards I 540 South: Fort Smith | 15.3 mi | |
| Continue onto OK 9 W | 2.7 mi | |
| Turn left onto North Pocola Boulevard (OK 112) | 17.0 mi | |
| Continue onto US 59 | 11.1 mi | |
| Turn left onto Old Highway 59 | 2.6 mi | |
| Turn right | 100 feet | |
| Turn left onto West 1st Street (US 59) | 15.8 mi | |
| Turn right onto US 259 | 10.2 mi | |
| Make a slight right onto Patterson Road | 1.2 mi | |
| Continue right onto LeFlore County Road N4700 | 500 feet | |
| Make a sharp left onto County Road D4697 | 3.6 mi | |
| Turn left onto County Road D1650 | 900 feet | |
| Turn right | 0.4 mi | |
| Turn right onto US 259 | 2.6 mi | |
| Turn right | 0.8 mi | |
| Turn right onto US 259 | 8.9 mi | |
| Turn left onto Choctaw Avenue (OK 4) | 1.4 mi | |
| Continue onto Highway 4 (Oklahoma) | 10.6 mi | |
| Continue onto Highway 4 (Arkansas) | 2.9 mi | |
| Turn right onto US 59 | 30.2 mi | |
| Turn left onto East Collin Raye Drive (US 59) | 8.0 mi | |
| Continue onto US 59 | 26.7 mi | |
| Turn right onto West Main Street (AR 32B) | 600 feet | |
| Turn left onto North 2nd Street | 500 feet | |
| You have arrived at your destination |
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Amana, Iowa - Ashdown, Arkansas