I 39 $south; US 51 $south, I 55 $south
234.7 mi3 hours 47 mins
| Head south on South Mason Avenue (US 52) | 800 feet | |
| Continue onto S Mason Avenue (US 52) | 6.9 mi | |
| Continue onto North Pennsylvania Avenue (US 52) | 7.9 mi | |
| Turn right onto US 52 | 0.4 mi | |
| Turn left onto Meriden Street | 0.5 mi | |
| Continue slightly right onto 12th Street | 0.2 mi | |
| Turn right onto 4th Avenue | 400 feet | |
| Make a sharp left onto 12th Street (US 34) | 1.0 mi | |
| Continue onto North 43rd Road (US 34) | 1.5 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 39 S | 71.3 mi | |
| Keep right towards I 55 South: Peoria | 7.6 mi | |
| Keep right towards I 55 South: Saint Louis | 64.7 mi | |
| Keep left towards I 55 South: Saint Louis | 62.8 mi | |
| Take the ramp towards IL 140: Alton | 0.3 mi | |
| Turn right onto East State Street (IL 140) | 0.2 mi | |
| Turn left onto South Old US Route 66 (IL 157) | 0.6 mi | |
| Continue onto North State Route 157 (IL 157) | 6.7 mi | |
| Continue onto Hillsboro Avenue (IL 157) | 0.6 mi | |
| Continue onto East Vandalia Street (IL 157) | 800 feet | |
| Turn right onto East Vandalia Street (IL 143) | 0.5 mi | |
| Turn right onto North Main Street (IL 143) | 700 feet | |
| Turn right onto Hillsboro Avenue | 400 feet | |
| You have arrived at your destination |
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Amboy, Illinois - Edwardsville, Illinois