US 76; GA 2, Long Creek Highway
121.7 mi2 hours 39 mins
| Head west on 2nd Street (US 19 Business) | 1.1 mi | |
| Continue onto Andrews Highway (US 19 Business) | 400 feet | |
| Turn left onto US 19 | 5.3 mi | |
| Turn left onto NC 141 | 8.7 mi | |
| Turn left onto US 64 | 9.4 mi | |
| Make a sharp right onto NC 69 | 3.5 mi | |
| Continue onto GA 17 | 1.1 mi | |
| Turn left onto US 76 | 31.2 mi | |
| Turn right onto US 23 | 0.3 mi | |
| Turn left onto Chechero Road (US 76) | 25.6 mi | |
| Turn left onto Toccoa Highway (US 123) | 500 feet | |
| Continue onto West Windsor Street (US 76) | 0.7 mi | |
| Continue onto East Main Street (US 76) | 1.6 mi | |
| Continue onto Old Seneca Road (US 76) | 800 feet | |
| Continue onto Sandifer Boulevard (US 76) | 5.7 mi | |
| Continue onto Bypass 123 (US 76) | 7.7 mi | |
| Continue onto Tiger Boulevard (US 76) | 1.4 mi | |
| Turn right onto Anderson Highway (US 76) | 5.6 mi | |
| Continue onto Clemson Boulevard (US 76) | 900 feet | |
| Continue onto Clemson Highway (US 76) | 4.5 mi | |
| Continue onto Clemson Boulevard (US 76) | 4.7 mi | |
| Turn right onto East North Avenue (US 76) | 1.2 mi | |
| Continue onto Club Drive (US 76) | 0.4 mi | |
| Go straight onto North Murray Avenue (US 76) | 1.2 mi | |
| Turn left onto West Market Street | 500 feet | |
| Turn right onto South Main Street (SC 28 Business) | 300 feet | |
| You have arrived at your destination |
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Andrews, North Carolina - Anderson, South Carolina