Dwight D. Eisenhower Highway, I 64 $east
1,269.2 mi18 hours 18 mins
| Head east on West 64th Avenue | 0.2 mi | |
| Turn right onto Wadsworth Bypass (CO 121) | 1.4 mi | |
| Continue onto Wadsworth Boulevard (CO 121) | 0.3 mi | |
| Take the ramp on the right towards I 70 | 400 feet | |
| Keep left towards I 70 East | 0.5 mi | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto I 70 E | 7.0 mi | |
| Keep left onto I 70 E | 172.7 mi | |
| Continue onto I 70 | 354.4 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 142.4 mi | |
| Keep right onto I 70 E | 8.0 mi | |
| Take the ramp towards I 64 East: Louisville | 0.6 mi | |
| Merge left onto I 64 E | 70.1 mi | |
| Keep right towards I 57 South | 4.6 mi | |
| Take the ramp on the left towards I 64 East: Louisville | 327.6 mi | |
| Take exit 41 towards KY 80: London | 900 feet | |
| Turn left onto Russell Dyche Memorial Highway (KY 80) | 0.6 mi | |
| Turn right onto North Main Street (US 25) | 1.5 mi | |
| You have arrived at your destination |
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Arvada, Colorado - London, Kentucky