US 61 $south, I 74 $east; IL 110 $west
324.2 mi6 hours 2 mins
| Head east on Main Street (WI 133) | 800 feet | |
| Continue onto State Highway 133 (WI 133) | 6.7 mi | |
| Continue onto State Highway 130 (WI 130) | 2.2 mi | |
| Make a slight right to stay on State Highway 130 (WI 130) | 8.7 mi | |
| Turn right onto State Highway 23 (WI 23) | 5.4 mi | |
| Continue onto North Bequette Street (WI 23) | 0.8 mi | |
| Continue onto State Highway 23 (WI 23) | 0.2 mi | |
| Continue onto North Iowa Street (WI 23) | 0.2 mi | |
| Continue onto State Highway 23 (WI 23) | 600 feet | |
| Continue onto South Iowa Street (WI 23) | 0.2 mi | |
| Continue onto State Highway 23 (WI 23) | 1.0 mi | |
| Keep right towards US 151 South: Mineral Point | 0.2 mi | |
| Merge left onto US Highway 151 (US 151) | 36.4 mi | |
| Continue onto Great River Road (US 61) | 7.7 mi | |
| Continue onto Dubuque-Wisconsin Bridge (US 61 S) | 67.9 mi | |
| Continue onto US 61 Business S | 0.4 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 80 | 52.8 mi | |
| Take exit 46A towards US 34 West: Monmouth | 16.9 mi | |
| Continue onto US 34 | 35.6 mi | |
| Turn left onto East Calhoun Street (US 67) | 800 feet | |
| Turn right onto North Campbell Street (US 67) | 800 feet | |
| Turn left onto East Jackson Street (US 67) | 2.7 mi | |
| Turn right onto East 1500th Street (US 67) | 35.3 mi | |
| Turn right onto US 67 | 14.3 mi | |
| Turn right onto Illinois Route 100 (IL 100) | 5.1 mi | |
| Go straight onto Illinois Route 100 (IL 100) | 5.3 mi | |
| Turn left | 0.4 mi | |
| Merge left onto I 72 E | 5.4 mi | |
| Take the ramp towards IL 106: Winchester | 0.4 mi | |
| Keep right towards IL 106: Winchester | 100 feet | |
| Go straight onto Old US Route 36 | 700 feet | |
| Go straight onto Old Route 36 | 3.5 mi | |
| Turn left onto Illinois Route 106 (IL 106) | 800 feet | |
| Continue onto West Cherry Street (IL 106) | 1.5 mi | |
| Continue onto Illinois Route 106 (IL 106) | 5.2 mi | |
| Make a sharp right onto Main Street | 500 feet | |
| Turn left onto Church Boulevard | 900 feet | |
| Turn left onto Alsey Smith Road | 200 feet | |
| You have arrived at your destination |
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Avoca, Wisconsin - Alsey, Illinois