I 79 $south, I 64 $west
650.8 mi10 hours 8 mins
| Head west on Hamilton Boulevard (US 222) | 0.5 mi | |
| Turn right onto Independent Road (PA 863) | 3.3 mi | |
| Continue onto Golden Key Road (PA 863) | 900 feet | |
| Take the ramp on the left towards I 78 West: Harrisburg | 0.2 mi | |
| Merge left onto William Penn Highway (I 78 W) | 36.6 mi | |
| Continue onto 78th Division Highway (I 78 W) | 7.6 mi | |
| Continue towards I 81 South: Harrisburg | 0.7 mi | |
| Merge left onto I 81 S | 96.4 mi | |
| Take the ramp towards I 70 East & West: Hancock | 0.2 mi | |
| Keep right towards I 70 West: Hancock | 0.4 mi | |
| Merge left onto Dwight D Eisenhower Highway (I 70) | 16.3 mi | |
| Continue onto I 70, US 40 (Dwight D Eisenhower Highway) (I 70 W) | 3.1 mi | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 5.0 mi | |
| Take the ramp on the left towards US 40: Cumberland | 80.5 mi | |
| Continue onto I 68 W | 31.3 mi | |
| Keep left towards I-79 S: Fairmont | 0.8 mi | |
| Merge left onto I 79 S | 147.8 mi | |
| Merge right onto I 77 S | 1.4 mi | |
| Take the ramp towards I 64 West: Huntington | 900 feet | |
| Keep left at the fork | 0.5 mi | |
| Merge right onto I 64 W | 167.7 mi | |
| Keep right towards I 64 West: Louisville | 6.9 mi | |
| Keep left towards I 64 West: Frankfort | 39.2 mi | |
| Take the ramp towards KY 53: Shelbyville | 0.3 mi | |
| Turn right onto Mount Eden Road (KY 53) | 1.8 mi | |
| Turn left onto Frankfort Road (US 60) | 600 feet | |
| Continue onto Washington Street (US 60) | 1.6 mi | |
| Turn left onto Smithfield Road (KY 53) | 200 feet | |
| You have arrived at your destination |
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Breinigsville, Pennsylvania - Shelbyville, Kentucky