I 81 $south, New York State Thruway
739.9 mi12 hours
| Head southwest | 700 feet | |
| Turn left | 200 feet | |
| Turn right onto Central Avenue West | 400 feet | |
| Turn right onto Stewart Boulevard | 0.3 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto Highway 401 (401 W) | 21.7 mi | |
| Take the ramp towards 137: Hill Island | 1.0 mi | |
| Continue onto Highway 137 (137) | 2.3 mi | |
| Continue onto Interstate 81 (I 81 S) | 4.3 mi | |
| Continue onto Thousand Islands Bridge (I 81 N) | 0.9 mi | |
| Make a slight right onto I 81 S | 89.8 mi | |
| Take exit 25A towards I 90: Albany | 0.5 mi | |
| Keep right towards I 90 West: Buffalo | 800 feet | |
| Merge left onto New York State Thruway (I 90 W) | 145.2 mi | |
| Keep left onto New York State Thruway (I 90 W) | 167.2 mi | |
| Keep left onto I 271 Express S | 13.6 mi | |
| Take the ramp towards I 271 South: Columbus | 0.2 mi | |
| Merge right onto Outerbelt East Freeway (I 271 S) | 5.4 mi | |
| Keep left onto I 271 S | 22.5 mi | |
| Merge left onto I 71 S | 112.0 mi | |
| Take the ramp towards Main Street | 0.3 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto East Main Street | 0.3 mi | |
| Turn left onto South Grant Avenue | 500 feet | |
| Turn right onto East Mound Street | 0.4 mi | |
| Turn left onto South Third Street (US 23) | 0.3 mi | |
| Turn right onto East Beck Street | 800 feet | |
| Turn left onto South High Street (US 23) | 8.3 mi | |
| Continue onto Portsmouth – Columbus Road (US 23) | 36.6 mi | |
| Keep right onto US 23 | 31.5 mi | |
| Take the ramp towards SR 823 South: Ironton | 0.5 mi | |
| Continue towards SR 823 South: Ironton | 16.6 mi | |
| Merge left onto US 52 E | 6.5 mi | |
| Take the ramp towards SR 253 | 0.3 mi | |
| Turn right onto Kenyon Road (SR 253) | 800 feet | |
| Continue onto Jesse Stuart Memorial Bridge (SR 253) | 0.7 mi | |
| Continue onto AA Highway (KY 10) | 0.6 mi | |
| Turn left onto US 23 | 8.6 mi | |
| Turn right onto Industrial Parkway (KY 67) | 14.0 mi | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto I 64 W | 6.3 mi | |
| Take exit 172 towards KY 1: Grayson | 0.3 mi | |
| Turn left onto Carol Malone Boulevard (KY 1) | 19.4 mi | |
| Turn right onto Brown Ridge Road (KY 32) | 300 feet | |
| You have arrived at your destination, on the left |
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Brockville, ON, Canada - Newfoundland, KY, USA