I 79 $south, I 77 $south
1,358.8 mi21 hours 3 mins
| Head south on South Elmwood Avenue (NY 5) | 0.2 mi | |
| Keep left onto South Elmwood Avenue (NY 5) | 200 feet | |
| Continue onto Buffalo Skyway (NY 5) | 4.8 mi | |
| Continue onto Hamburg Turnpike (NY 5) | 1.2 mi | |
| Continue onto Lake Shore Road (NY 5) | 0.7 mi | |
| Continue onto Hamburg Turnpike (NY 5) | 400 feet | |
| Take the ramp towards NY 179 East: Woodlawn Beach | 900 feet | |
| Enter the roundabout and take the 3rd exit onto Milestrip Expressway (NY 179) | 0.2 mi | |
| Exit the roundabout onto Milestrip Expressway (NY 179) | 1.1 mi | |
| Continue onto Milestrip Road (NY 179) | 0.2 mi | |
| Take the ramp on the left | 0.3 mi | |
| Keep right towards I 90 West: Erie | 800 feet | |
| Merge left onto New York State Thruway (I 90 W) | 87.8 mi | |
| Take the ramp towards I-79 South: Pittsburgh | 0.5 mi | |
| Merge left onto I 79 S | 106.0 mi | |
| Keep right onto I 79 S | 33.8 mi | |
| Keep left towards I 70 East: New Stanton | 3.5 mi | |
| Take the ramp towards I-79 south: Morgantown | 136.3 mi | |
| Take the ramp towards US 19 South: Beckley | 0.3 mi | |
| Keep right onto US 19 S | 68.8 mi | |
| Keep left towards I 64 East: Bluefield | 1.1 mi | |
| Merge left onto West Virginia Turnpike (I 64 E) | 46.3 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 8.7 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 101.2 mi | |
| Keep right onto I 77 S | 109.4 mi | |
| Keep left onto I 77 S | 18.4 mi | |
| Keep left towards I 26 South: Charleston | 0.8 mi | |
| Merge right onto I 26 E | 52.0 mi | |
| Take the ramp towards I 95 South: Savannah | 0.9 mi | |
| Merge left onto I 95 S | 217.5 mi | |
| Take the ramp towards I 295 West Beltway: Orange Park | 0.6 mi | |
| Continue onto I 295 S | 13.8 mi | |
| Take the ramp towards I-10 West | 0.4 mi | |
| Merge left onto I 10 W | 12.6 mi | |
| Take the ramp towards US 301: Baldwin | 0.2 mi | |
| Keep right at the fork | 600 feet | |
| Merge left onto US 301 | 36.7 mi | |
| Keep left onto Sid Martin Highway (US 301) | 39.1 mi | |
| Turn right onto Northwest 70th Street (FL 326) | 1.7 mi | |
| Continue onto NW 77th Street (FL 326) | 0.9 mi | |
| Continue onto CR 326 | 0.2 mi | |
| Take the ramp on the left | 0 feet | |
| Turn left onto CR 326 | 1,000 feet | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 75 S | 29.1 mi | |
| Keep right towards I 75 South: Tampa | 53.5 mi | |
| Keep left towards South I 75: Naples | 16.2 mi | |
| Continue onto I 75 S | 58.3 mi | |
| Keep left onto I 75 S | 63.9 mi | |
| Take the ramp towards SR 884: Fort Myers | 0.3 mi | |
| Keep right towards SR 884: Colonial Blvd | 300 feet | |
| Merge left onto Colonial Boulevard (FL 884) | 1.1 mi | |
| Turn right onto Winkler Avenue | 0.2 mi | |
| Turn right onto Province Park Boulevard | 0.2 mi | |
| Turn left onto Milan Drive | 200 feet | |
| You have arrived at your destination |
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Buffalo, New York - Fort Myers, Florida