How to get from Buffalo, New York to Knoxville, Tennessee

Discover, print or download the driving directions for the best route to go from Buffalo, New York to Knoxville, Tennessee.

Enlarge the route map Buffalo, New York - Knoxville, Tennessee

Driving directions from Buffalo, New York to Knoxville, Tennessee

I 71 $south, I 75 $south

684.3 mi10 hours 26 mins

Head south on Delaware Avenue (NY 384) 600 feet
Turn right onto Church Street 200 feet
Make a sharp left onto Buffalo Skyway (NY 5) 4.8 mi
Continue onto Hamburg Turnpike (NY 5) 1.2 mi
Continue onto Lake Shore Road (NY 5) 0.7 mi
Continue onto Hamburg Turnpike (NY 5) 400 feet
Take the ramp towards NY 179 East: Woodlawn Beach 900 feet
Enter the roundabout and take the 3rd exit onto Milestrip Expressway (NY 179) 0.2 mi
Exit the roundabout onto Milestrip Expressway (NY 179) 1.1 mi
Continue onto Milestrip Road (NY 179) 0.2 mi
Take the ramp on the left 0.3 mi
Keep right towards I 90 West: Erie 800 feet
Merge left onto New York State Thruway (I 90 W) 163.4 mi
Keep left onto I 271 Express S 13.6 mi
Take the ramp towards I 271 South: Columbus 0.2 mi
Merge right onto Outerbelt East Freeway (I 271 S) 5.4 mi
Keep left onto I 271 S 22.5 mi
Merge left onto I 71 S 112.7 mi
Merge right onto South Innerbelt (I 70) 1.1 mi
Take the ramp on the left towards I 71 South: Cincinnati 900 feet
Keep left towards I 71 South: Cincinnati 0.6 mi
Merge left onto South Freeway (I 71 S) 69.6 mi
Continue onto I 71 W 3.5 mi
Continue onto I 71 S 30.7 mi
Keep left onto Northeast Expressway (I 71 S) 0.6 mi
Continue onto Lytle Tunnel (I 71 S) 1.5 mi
Continue onto Brent Spence Bridge (I 71 S) 245.7 mi
Continue onto I 275 S 2.9 mi
Keep right towards I 40 East: Asheville 0.3 mi
Keep right at the fork 600 feet
Keep left at the fork 0.5 mi
Go straight onto Henley Street (US 11) 0.2 mi
You have arrived at your destination

Print directions
Buffalo, New York - Knoxville, Tennessee

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.