Autoestrada do Sul, Autovía del Quinto Centenario
373.9 mi5 hours 24 mins
| Head north on Passeio Dom Luís I | 400 feet | |
| Continue left onto Avenida Combatentes da Grande Guerra | 600 feet | |
| Enter the roundabout and take the 2nd exit onto Avenida Marginal | 100 feet | |
| Exit the roundabout onto Avenida Marginal | 0.3 mi | |
| Enter the roundabout and take the 2nd exit onto Avenida de Sintra (EN 9) | 200 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 700 feet | |
| Enter the roundabout and take the 2nd exit onto Avenida de Sintra (EN 9) | 100 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 0.3 mi | |
| Enter the roundabout and take the 1st exit onto Avenida de Sintra (EN 9) | 0 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 0.2 mi | |
| Continue straight onto Avenida de Sintra (EN 9) | 0.3 mi | |
| Enter the roundabout and take the 2nd exit onto Avenida de Sintra (EN 9) | 300 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 700 feet | |
| Continue slightly right onto Variante à EN 9 (EN 9) | 0.3 mi | |
| Enter the roundabout and take the 1st exit onto Avenida de Sintra (EN 9) | 100 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 900 feet | |
| Enter Avenida de Sintra and take the 2nd exit onto Avenida de Sintra (EN 9) | 100 feet | |
| Exit the roundabout onto Avenida de Sintra (EN 9) | 0 feet | |
| Keep right towards A 5: Lisboa | 0.2 mi | |
| Merge left onto A 5 | 13.4 mi | |
| Take the ramp towards Praça de Espanha | 0.4 mi | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto Autoestrada do Sul (A 2) | 149.1 mi | |
| Keep left at the fork | 0.4 mi | |
| Merge left onto Via do Infante (A 22) | 49.6 mi | |
| Continue onto Puente Internacional del Guadiana (A-49) | 900 feet | |
| Continue onto Autovía del Quinto Centenario (A-49) | 82.4 mi | |
| Keep right towards SE-30: Coria del Río | 0.5 mi | |
| Merge left onto SE-30 | 4.1 mi | |
| Take the ramp towards Puerto este | 600 feet | |
| Keep left towards E-5 A-4 Cádiz | 0.2 mi | |
| Merge left onto Autovía del Sur (A-4) | 7.8 mi | |
| Continue onto Autopista del Sur (AP-4R) | 19.8 mi | |
| Keep left onto Autopista del Sur (AP-4) | 37.7 mi | |
| Continue onto Autovía de Acceso a Cádiz (CA-35) | 1.3 mi | |
| Keep left onto Autovía de Acceso a Cádiz (CA-35) | 0.5 mi | |
| Continue onto Viaducto del Río San Pedro (CA-35) | 0.5 mi | |
| Continue onto Puente de la Constitución de 1812 (CA-35) | 2.1 mi | |
| Continue onto Avenida de las Cortes de Cádiz | 0.5 mi | |
| Enter the roundabout and take the 1st exit onto Avenida de los Astilleros | 0 feet | |
| Exit the roundabout onto Avenida de los Astilleros | 200 feet | |
| Go straight onto Avenida de Astilleros | 0.6 mi | |
| Continue onto Plaza de Sevilla | 500 feet | |
| Make a sharp left onto Cuesta de las Calesas | 100 feet | |
| You have arrived at your destination |
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Cascais, Lisboa - Cádiz, Andalucía