US 60, US 160
260.9 mi4 hours 50 mins
| Head east on East Noleman Street (IL 161) | 300 feet | |
| Turn right onto North Maple Street | 500 feet | |
| Turn right onto East Broadway | 900 feet | |
| Turn left onto South Poplar Street (US 51) | 10.5 mi | |
| Take the ramp on the left towards Mount Vernon | 0.3 mi | |
| Merge left onto I 64 E | 12.1 mi | |
| Keep right towards I 57 South | 13.0 mi | |
| Continue onto I 57 S | 151.1 mi | |
| Keep left onto US 60 | 6.1 mi | |
| Continue onto US 67 | 0.3 mi | |
| Keep left onto US 67 | 9.7 mi | |
| Take the ramp | 0.3 mi | |
| Turn right onto 158 | 0.2 mi | |
| Continue onto US 160 | 19.8 mi | |
| Turn right to stay on US 160 | 28.3 mi | |
| Continue straight to stay on US 160 | 8.7 mi | |
| Turn right onto US 160 | 400 feet | |
| You have arrived at your destination |
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Centralia, Illinois - Alton, Missouri