US 20 $east, I 74 $east
1,327.3 mi20 hours 52 mins
| Head south on South 2nd Street (US 59) | 17.1 mi | |
| Continue onto North Main Street (US 59) | 2.0 mi | |
| Take the ramp on the left onto US 59 S | 8.0 mi | |
| Continue onto 220th Street (US 20 E) | 165.5 mi | |
| Take the ramp towards I 380 South: Cedar Rapids | 49.2 mi | |
| Continue onto I 380 S | 16.1 mi | |
| Take the ramp towards I 80 East: Iowa City | 0.3 mi | |
| Merge left onto I 80 | 182.9 mi | |
| Continue onto I 74 E | 7.5 mi | |
| Keep right towards I 55 South | 6.4 mi | |
| Keep left towards I 74 East: Indianapolis | 80.8 mi | |
| Take the ramp towards US 150 | 1,000 feet | |
| Keep left towards US 150 West | 1,000 feet | |
| Keep left towards I 74 East | 0.3 mi | |
| Merge left onto I 74 E | 78.2 mi | |
| Take the ramp towards I-465 north | 600 feet | |
| Keep left towards US 136 West: Crawfordsville Road | 0.4 mi | |
| Turn left onto Crawfordsville Road (US 136) | 2.2 mi | |
| Enter the roundabout and take the 1st exit onto West 16th Street | 100 feet | |
| Exit the roundabout onto West 16th Street | 3.0 mi | |
| Turn right onto Indiana Avenue | 0.7 mi | |
| Turn left onto West 10th Street | 0.4 mi | |
| Turn left onto North West Street | 500 feet | |
| Keep left at the fork | 0.5 mi | |
| Merge right onto I 65 S | 0.7 mi | |
| Take exit 112A on the left towards I 70 East: Dayton | 0.4 mi | |
| Merge right onto I 70 | 98.5 mi | |
| Take the ramp towards SR 49 South: Clayton | 9.9 mi | |
| Turn right onto West Riverview Avenue | 400 feet | |
| Go straight onto Edwin C. Moses Boulevard | 0.3 mi | |
| Turn left onto West 3rd Street | 0.7 mi | |
| Turn right onto South Ludlow Street (SR 48) | 0.5 mi | |
| Take the ramp | 0.5 mi | |
| Merge left onto US 35 E | 11.7 mi | |
| Keep right towards US 35: Washington Court House | 66.8 mi | |
| Keep left onto US 35 E | 58.6 mi | |
| Keep right onto US 35 E | 0.6 mi | |
| Continue onto Silver Memorial Bridge (US 35 S) | 10.0 mi | |
| Continue onto US 35 | 19.7 mi | |
| Continue onto US 35 S | 6.9 mi | |
| Turn left onto County Route 33 | 100 feet | |
| Turn left onto US 35 N | 400 feet | |
| Take the ramp | 0.5 mi | |
| Merge left onto I 64 E | 118.2 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 8.7 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 37.3 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 30.7 mi | |
| Take the ramp towards I 40 Business East: Kernersville | 800 feet | |
| Merge left onto I 40 Business E | 2.0 mi | |
| Continue onto I 40 Business E | 11.2 mi | |
| Merge left onto I 40 | 4.8 mi | |
| Keep right onto I 40 | 7.8 mi | |
| Merge right onto I 40 | 1.8 mi | |
| Keep left onto I 40 | 36.7 mi | |
| Keep right towards I 40 East: Raleigh | 30.3 mi | |
| Keep right towards Wade Avenue | 3.3 mi | |
| Take the ramp towards I 440 East: Wake Forest | 0.2 mi | |
| Merge left onto I 440 E | 9.5 mi | |
| Take the ramp towards I 87 North: Wilson | 0.7 mi | |
| Continue onto I 87 N | 3.1 mi | |
| Continue onto I-87 | 13.7 mi | |
| Keep right onto US 264 E | 18.6 mi | |
| Continue onto I 795 E | 4.5 mi | |
| Keep left onto US 264 E | 33.2 mi | |
| Continue onto Stantonsburg Road | 2.0 mi | |
| Turn left onto South Memorial Drive (US 13) | 0.4 mi | |
| Turn right onto West 5th Street | 0.7 mi | |
| You have arrived at your destination |
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Cherokee, Iowa - Greenville, North Carolina