I 74 $east, I 75 $south
1,001.3 mi15 hours 56 mins
| Head south on North 2nd Street | 200 feet | |
| Turn right onto West Walnut Street | 800 feet | |
| Turn left onto North 4th Street (IL 29) | 15.2 mi | |
| Continue straight to stay on Northeast Adams Street (IL 29) | 0.9 mi | |
| Continue onto Northeast Jefferson Avenue (IL 29) | 1.7 mi | |
| Take the ramp on the left onto IL 29 | 0.2 mi | |
| Merge left onto Interstate 74 Bridge (I 74 E) | 33.1 mi | |
| Keep right towards I 55 South | 6.4 mi | |
| Keep left towards I 74 East: Indianapolis | 80.8 mi | |
| Take the ramp towards US 150 | 1,000 feet | |
| Keep left towards US 150 West | 1,000 feet | |
| Keep left towards I 74 East | 0.3 mi | |
| Merge left onto I 74 E | 85.4 mi | |
| Continue onto I 74 | 0.4 mi | |
| Continue onto I 74 E | 8.3 mi | |
| Take exit 53B towards I 65 South: Louisville | 0.5 mi | |
| Merge left onto I 65 S | 106.2 mi | |
| Take the ramp towards I 64: Lexington | 100 feet | |
| Keep left towards I 64 East: Lexington | 0.8 mi | |
| Merge left onto I 64 E | 175.4 mi | |
| Continue onto I 75 S | 64.6 mi | |
| Continue onto I 275 S | 0.3 mi | |
| Take the ramp towards I 640 East: Asheville | 0.2 mi | |
| Merge left onto I 640 E | 6.7 mi | |
| Keep left towards I 40 East: Asheville | 28.5 mi | |
| Keep right towards I 40 East: Asheville | 76.3 mi | |
| Take the ramp towards I 26 East: Hendersonville | 13.3 mi | |
| Continue onto I 26 E | 134.0 mi | |
| Take the ramp towards I 20 East: Florence | 0.3 mi | |
| Merge left onto I 20 | 79.3 mi | |
| Turn left onto West Palmetto Street (US 76) | 22.6 mi | |
| Go straight onto SC 576 S | 3.1 mi | |
| Continue onto US 501 Business | 21.0 mi | |
| Take the ramp | 1.0 mi | |
| Continue onto Veterans Highway (SC 22 E) | 26.2 mi | |
| Take the ramp towards SC 31 North: Little River | 0.3 mi | |
| Merge left onto Carolina Bays Parkway (SC 31 N) | 5.1 mi | |
| Take the ramp towards Robert Edge Pkwy: North Myrtle Beach | 0.2 mi | |
| Turn right onto Robert Edge Parkway | 1.7 mi | |
| Turn right onto US 17 | 0.3 mi | |
| Turn right onto 2nd Ave South | 0.2 mi | |
| You have arrived at your destination |
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Chillicothe, Illinois - North Myrtle Beach, South Carolina