How to get from Cincinnati, Ohio to Knoxville, Tennessee

Discover, print or download the driving directions for the best route to go from Cincinnati, Ohio to Knoxville, Tennessee.

Enlarge the route map Cincinnati, Ohio - Knoxville, Tennessee

Driving directions from Cincinnati, Ohio to Knoxville, Tennessee

I 71 $south; I 75 $south, I 75 $south

253.6 mi3 hours 49 mins

Head northeast on Ohio Avenue 100 feet
Turn right onto West McMillan Avenue 900 feet
Continue onto East McMillan Street 0.4 mi
Turn right onto Maplewood Avenue 600 feet
Turn left onto Kinsey Avenue 800 feet
Turn right onto Reading Road (US 42) 0.5 mi
Turn left towards I 71 South: Eden Park Drive 200 feet
Take the ramp towards I 71 South 0.3 mi
Merge right onto Northeast Expressway (I 71 S) 0.2 mi
Keep left onto Northeast Expressway (I 71 S) 0.6 mi
Continue onto Lytle Tunnel (I 71 S) 1.5 mi
Continue onto Brent Spence Bridge (I 71 S) 245.7 mi
Continue onto I 275 S 2.9 mi
Keep right towards I 40 East: Asheville 0.3 mi
Keep right at the fork 600 feet
Keep left at the fork 0.5 mi
Go straight onto Henley Street (US 11) 0.2 mi
You have arrived at your destination

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Cincinnati, Ohio - Knoxville, Tennessee

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