I 75 $south, I 26 $east
667.7 mi10 hours 18 mins
| Head northeast on Ohio Avenue | 100 feet | |
| Turn right onto West McMillan Avenue | 900 feet | |
| Continue onto East McMillan Street | 0.4 mi | |
| Turn right onto Maplewood Avenue | 600 feet | |
| Turn left onto Kinsey Avenue | 800 feet | |
| Turn right onto Reading Road (US 42) | 0.5 mi | |
| Turn left towards I 71 South: Eden Park Drive | 200 feet | |
| Take the ramp towards I 71 South | 0.3 mi | |
| Merge right onto Northeast Expressway (I 71 S) | 0.2 mi | |
| Keep left onto Northeast Expressway (I 71 S) | 0.6 mi | |
| Continue onto Lytle Tunnel (I 71 S) | 1.5 mi | |
| Continue onto Brent Spence Bridge (I 71 S) | 245.7 mi | |
| Continue onto I 275 S | 0.3 mi | |
| Take the ramp towards I 640 East: Asheville | 0.2 mi | |
| Merge left onto I 640 E | 6.7 mi | |
| Keep left towards I 40 East: Asheville | 28.5 mi | |
| Keep right towards I 40 East: Asheville | 76.3 mi | |
| Take the ramp towards I 26 East: Hendersonville | 13.3 mi | |
| Continue onto I 26 E | 134.6 mi | |
| Keep right towards Charleston | 60.3 mi | |
| Take the ramp towards I 95 South: Savannah | 0.9 mi | |
| Merge left onto I 95 S | 80.1 mi | |
| Take the ramp towards US 17: Hardeeville | 0.3 mi | |
| Turn right onto Whyte Hardee Boulevard (US 17) | 500 feet | |
| Continue onto General William Hardee Boulevard (US 17) | 13.0 mi | |
| Continue onto Eugene Talmadge Memorial Bridge (US 17) | 0.6 mi | |
| Continue onto Atlantic Coastal Highway (US 17 S) | 1.3 mi | |
| Take the ramp towards GA 25: Savannah | 0.9 mi | |
| Turn left onto Martin Luther King Junior Boulevard (GA 25 Connector) | 0.3 mi | |
| Turn right onto West Bay Street | 0.3 mi | |
| You have arrived at your destination |
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Cincinnati, Ohio - Savannah, Georgia