I 71 $south; I 75 $south, I 75 $south
961.2 mi14 hours 28 mins
| Head northeast on Ohio Avenue | 100 feet | |
| Turn right onto West McMillan Avenue | 900 feet | |
| Continue onto East McMillan Street | 0.4 mi | |
| Turn right onto Maplewood Avenue | 600 feet | |
| Turn left onto Kinsey Avenue | 800 feet | |
| Turn right onto Reading Road (US 42) | 0.5 mi | |
| Turn left towards I 71 South: Eden Park Drive | 200 feet | |
| Take the ramp towards I 71 South | 0.3 mi | |
| Merge right onto Northeast Expressway (I 71 S) | 0.2 mi | |
| Keep left onto Northeast Expressway (I 71 S) | 0.6 mi | |
| Continue onto Lytle Tunnel (I 71 S) | 1.5 mi | |
| Continue onto Brent Spence Bridge (I 71 S) | 245.7 mi | |
| Take the ramp towards I 75 South: Nashville | 3.5 mi | |
| Keep right towards I 75 South: Nashville | 17.1 mi | |
| Keep left towards I 75 South: Chattanooga | 10.2 mi | |
| Keep right onto I 75 S | 800 feet | |
| Keep left onto I 75 S | 49.5 mi | |
| Take the ramp towards SR 60: Cleveland | 1,000 feet | |
| Turn right onto Georgetown Road Northwest (TN 60) | 1,000 feet | |
| Continue onto 25th Street Northwest (TN 60) | 4.1 mi | |
| Continue onto Appalachian Highway (US 74) | 1.7 mi | |
| Turn left onto McGrady Drive Southeast (TN 60) | 0.2 mi | |
| Turn left onto Dalton Pike (TN 60) | 10.7 mi | |
| Continue onto Cleveland Road (GA 71) | 9.1 mi | |
| Continue onto Cleveland Highway (GA 71) | 4.5 mi | |
| Turn right onto North Bypass (US 41) | 2.1 mi | |
| Continue onto Chattanooga Road (US 41) | 0.6 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 75 S | 90.3 mi | |
| Continue onto James Wendell George Parkway (I 75 S) | 2.3 mi | |
| Keep left onto I 75 S | 64.9 mi | |
| Take the ramp towards I 475 South: Valdosta | 15.6 mi | |
| Keep left towards I 75 South: Valdosta | 0.6 mi | |
| Merge left onto I 75 S | 300.1 mi | |
| Keep right towards I 75 South: Tampa | 53.5 mi | |
| Keep left towards South I 75: Naples | 16.2 mi | |
| Continue onto I 75 S | 47.8 mi | |
| Take the ramp towards FL 780: Fruitville Road | 0.2 mi | |
| Keep right at the fork | 0.2 mi | |
| Go straight onto Fruitville Road (FL 780) | 5.5 mi | |
| Turn left onto North Orange Avenue | 900 feet | |
| Turn left onto Main Street | 0 feet | |
| You have arrived at your destination, on the left |
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Cincinnati, Ohio - Sarasota, Florida