How to get from Clarksdale, Mississippi to Greenville, Mississippi

Discover, print or download the driving directions for the best route to go from Clarksdale, Mississippi to Greenville, Mississippi.

Enlarge the route map Clarksdale, Mississippi - Greenville, Mississippi

Driving directions from Clarksdale, Mississippi to Greenville, Mississippi

US 61; US 278, US 82; US 278

73.0 mi1 hour 22 mins

Head west on East 2nd Street 900 feet
Turn left onto Riverside Avenue 0.4 mi
Continue onto Madison Avenue 0.4 mi
Turn right onto South State Street (MS 161) 2.1 mi
Turn right onto US 61 16.9 mi
Go straight onto US 61 42.4 mi
Take the ramp onto US 278 10.6 mi
You have arrived at your destination

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Clarksdale, Mississippi - Greenville, Mississippi

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