Dwight D. Eisenhower Highway, I 40
1,557.8 mi23 hours 18 mins
| Head south on South Nevada Avenue | 400 feet | |
| Turn left onto East Colorado Avenue | 0.4 mi | |
| Continue onto East Pikes Peak Avenue | 1.1 mi | |
| Turn left onto North Union Boulevard | 0.3 mi | |
| Turn right onto East Platte Avenue | 32.0 mi | |
| Continue onto 5th Street (US 24) | 1.1 mi | |
| Continue onto United States Highway 24 (US 24) | 13.3 mi | |
| Continue onto Caribou Street (US 24) | 0.6 mi | |
| Continue onto United States Highway 24 (US 24) | 7.1 mi | |
| Continue onto US 24 | 16.2 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 70 E | 89.7 mi | |
| Continue onto I 70 | 354.4 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 142.4 mi | |
| Keep right onto I 70 E | 8.0 mi | |
| Take the ramp towards I 64 East: Louisville | 0.6 mi | |
| Merge left onto I 64 E | 70.1 mi | |
| Keep right towards I 57 South | 13.0 mi | |
| Continue onto I 57 S | 38.8 mi | |
| Take the ramp towards I 24 East: Nashville | 1.4 mi | |
| Continue onto I 24 E | 175.1 mi | |
| Keep right towards I 24 East: Nashville | 2.3 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep left towards I 40 East: Knoxville | 210.2 mi | |
| Keep right towards I 40 East: Asheville | 76.3 mi | |
| Take the ramp towards I 26 East: Hendersonville | 13.3 mi | |
| Continue onto I 26 E | 44.7 mi | |
| Take the ramp towards I 85 North: Charlotte | 0.2 mi | |
| Merge left onto I 85 N | 31.4 mi | |
| Take the ramp towards SC 198: Blacksburg | 0.3 mi | |
| Continue onto S-11-352 | 500 feet | |
| Make a sharp right onto North Mountain Street (SC 5) | 1.1 mi | |
| Continue onto York Road (SC 5) | 1.5 mi | |
| Continue onto York Highway (SC 5) | 4.1 mi | |
| Continue onto Kings Creek Drive (SC 5) | 1.1 mi | |
| Continue onto Cannan Church Road (SC 5) | 0.5 mi | |
| Continue onto Black Highway (SC 5) | 10.3 mi | |
| Continue onto West Liberty Street (SC 5 Business) | 3.4 mi | |
| Continue onto Old York Road (SC 5 Business) | 900 feet | |
| Turn right onto Alexander Love Highway (SC 5) | 800 feet | |
| Continue onto York Highway (SC 5) | 6.5 mi | |
| Continue onto West Main Street (SC 5) | 3.9 mi | |
| Turn right onto West Black Street | 0.7 mi | |
| You have arrived at your destination |
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Colorado Springs, Colorado - Rock Hill, South Carolina