How to get from Columbia, SC to Knoxville, TN

Discover, print or download the driving directions for the best route to go from Columbia, SC to Knoxville, TN.

Enlarge the route map Columbia, SC - Knoxville, TN

Driving directions from Columbia, SC to Knoxville, TN

I 26 $west, I 40

262.5 mi4 hours 9 mins

Head north on Huger Street (US 21) 0.6 mi
Take the ramp onto US 21 N 400 feet
Keep left at the fork 0.6 mi
Merge right onto I 126 W 3.2 mi
Merge left onto I 26 W 134.4 mi
Continue onto I 26 W 12.7 mi
Take the ramp on the left towards I 40 West: Canton 108.5 mi
Take exit 388A towards SR 158 West: Downtown 0.3 mi
Keep right at the fork 400 feet
Keep left at the fork 400 feet
Turn left onto Hall of Fame Drive 0.6 mi
Turn right onto US 11 0.5 mi
Make a slight right to stay on West 5th Avenue (US 11) 200 feet
Turn left onto North Broadway (US 11) 0.5 mi
Continue onto Henley Street (US 11) 0.3 mi
You have arrived at your destination

Print directions
Columbia, SC - Knoxville, TN

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.