US 23, US 35 $east
107.0 mi2 hours
| Head north on North Front Street | 200 feet | |
| Turn right onto West Gay Street | 0.2 mi | |
| Turn right onto North Third Street (US 23) | 0.3 mi | |
| Turn left onto East Town Street | 0.2 mi | |
| Turn right onto South Fifth Street | 0.3 mi | |
| Turn right onto East Mound Street | 0.2 mi | |
| Turn left onto South Third Street (US 23) | 0.3 mi | |
| Turn right onto East Beck Street | 800 feet | |
| Turn left onto South High Street (US 23) | 8.3 mi | |
| Continue onto Portsmouth – Columbus Road (US 23) | 36.6 mi | |
| Keep left onto US 35 E | 58.6 mi | |
| Keep right onto US 35 E | 0.6 mi | |
| Continue onto Silver Memorial Bridge (US 35 S) | 0.6 mi | |
| Take the ramp towards WV 2 North: Point Pleasant | 0.3 mi | |
| Merge left onto WV 2 | 0.3 mi | |
| Turn right onto Chestnut Street (CR 35/11) | 100 feet | |
| You have arrived at your destination |
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Columbus, Ohio - Henderson, West Virginia