How to get from Columbus, Ohio to Knoxville, Tennessee

Discover, print or download the driving directions for the best route to go from Columbus, Ohio to Knoxville, Tennessee.

Enlarge the route map Columbus, Ohio - Knoxville, Tennessee

Driving directions from Columbus, Ohio to Knoxville, Tennessee

I 71 $south, I 75 $south

358.9 mi5 hours 26 mins

Head north on North Front Street 0.2 mi
Turn left onto West Spring Street (US 33) 0.8 mi
Continue onto Dublin Road (US 33) 0.5 mi
Make a U-turn and continue on Dublin Road (US 33) 0.2 mi
Turn left 0.4 mi
Merge left onto West Innerbelt (SR 315 S) 0.9 mi
Continue onto South Freeway (SR 315 S) 70.0 mi
Continue onto I 71 W 3.5 mi
Continue onto I 71 S 30.7 mi
Keep left onto Northeast Expressway (I 71 S) 0.6 mi
Continue onto Lytle Tunnel (I 71 S) 1.5 mi
Continue onto Brent Spence Bridge (I 71 S) 245.7 mi
Continue onto I 275 S 2.9 mi
Keep right towards I 40 East: Asheville 0.3 mi
Keep right at the fork 600 feet
Keep left at the fork 0.5 mi
Go straight onto Henley Street (US 11) 0.2 mi
You have arrived at your destination

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Columbus, Ohio - Knoxville, Tennessee

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