I 20; I 59 $south, I 59 $south
390.4 mi5 hours 56 mins
| Head northwest on 2nd Avenue Southwest (US 31) | 200 feet | |
| Turn left onto 3rd Street Southwest (US 278) | 0.3 mi | |
| Continue onto 4th Street Southwest (US 278) | 1.6 mi | |
| Turn left | 0.2 mi | |
| Merge left onto Heroes Highway (I 65 S) | 46.5 mi | |
| Take the ramp towards I 20 West: Tuscaloosa | 0.4 mi | |
| Merge left onto I 20 | 146.0 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 106.4 mi | |
| Keep left at the fork | 1.0 mi | |
| Merge right onto I 10 | 32.1 mi | |
| Take the ramp towards Superdome | 800 feet | |
| Keep right onto Cleveland Avenue | 300 feet | |
| Turn right onto South Claiborne Avenue | 600 feet | |
| Turn left onto Tulane Avenue | 0.2 mi | |
| Turn right onto Lasalle Street | 700 feet | |
| You have arrived at your destination |
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Cullman, Alabama - New Orleans, Louisiana