I 57 $south, Interstate 57
278.4 mi4 hours 52 mins
| Head south on North Vermilion Street (US 136) | 1.2 mi | |
| Turn right onto East Main Street (IL 1) | 0.3 mi | |
| Turn left to stay on East Main Street (US 150) | 300 feet | |
| Continue onto Memorial Bridge (US 150) | 1,000 feet | |
| Continue onto Georgetown Road (US 150) | 0.9 mi | |
| Take the ramp on the right towards I 74 West | 0.5 mi | |
| Merge left onto I 74 W | 34.9 mi | |
| Take exit 179A towards I 57 South: Memphis | 0.3 mi | |
| Merge left onto I 57 S | 79.7 mi | |
| Keep left towards I 57 South: Memphis | 127.5 mi | |
| Take the ramp towards IL 146: Anna | 0.2 mi | |
| Turn right onto 770N (IL 146) | 400 feet | |
| Continue onto E Vienna St (IL 146) | 3.9 mi | |
| Go straight onto East Vienna Street (IL 146) | 1.9 mi | |
| Turn left onto Broad Street (IL 146) | 1.4 mi | |
| Turn left to stay on Public Square | 200 feet | |
| Make a slight right onto West Broad Street (IL 127) | 1,000 feet | |
| Continue onto Willards Ferry Road (IL 127) | 0.5 mi | |
| Go straight onto 1325E (IL 127) | 2.8 mi | |
| Continue onto 825N (IL 146) | 0.7 mi | |
| Continue onto 1050E (IL 146) | 1.7 mi | |
| Continue onto 785N (IL 146) | 1.9 mi | |
| Turn left to stay on State Route 3 South (IL 3) | 1.9 mi | |
| Continue onto 675E (IL 3) | 8.0 mi | |
| Continue onto Illinois State Route 3 (IL 3) | 1.7 mi | |
| Turn right onto IL 146 W | 4.1 mi | |
| Turn right onto South Fountain Street | 0.2 mi | |
| Enter the roundabout and take the 3rd exit onto Morgan Oak Street (MO 177) | 200 feet | |
| Exit the roundabout onto Morgan Oak Street (MO 177) | 0.3 mi | |
| Turn right onto South Sprigg Street | 0.2 mi | |
| Turn left onto William Street | 0.9 mi | |
| You have arrived at your destination |
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Danville, Illinois - Cape Girardeau, Missouri