New York State Thruway, Massachusetts Turnpike
1,116.8 mi17 hours 58 mins
| Head north on Schaefer Road | 0 feet | |
| Turn right onto Michigan Avenue (US 12) | 0.6 mi | |
| Take the ramp on the right towards I 94 East: Ford Freeway | 0.3 mi | |
| Merge left onto Detroit Industrial Expressway (I 94 E) | 0.3 mi | |
| Continue onto Edsel Ford Freeway (I 94 E) | 21.1 mi | |
| Continue onto Ford Freeway (I 94 E) | 44.8 mi | |
| Continue onto CBSA - Sarnia (Point Edward) Point Of Entry Traveler Lanes (402 E) | 63.9 mi | |
| Merge left onto Highway 401 (401 E) | 31.1 mi | |
| Keep right towards 403: Brantford | 39.9 mi | |
| Take the ramp towards Lincoln M. Alexander Parkway | 0.7 mi | |
| Continue onto Lincoln M. Alexander Parkway | 6.2 mi | |
| Continue onto Red Hill Valley Parkway | 5.3 mi | |
| Keep right towards QEW: Niagara | 1.2 mi | |
| Merge left onto Queen Elizabeth Way (QEW S) | 30.8 mi | |
| Keep left towards 405: Queenston | 5.8 mi | |
| Continue onto Queenston–Lewiston Bridge (405) | 800 feet | |
| Continue onto Lewiston-Queenston Bridge (I 190) | 14.7 mi | |
| Take exit 16 towards I 290 East: Tonawanda | 0.4 mi | |
| Continue onto Youngmann Expressway (I 290 E) | 9.4 mi | |
| Keep left towards I 90 East: Albany | 0.6 mi | |
| Merge left onto New York State Thruway (I 90 E) | 285.1 mi | |
| Take exit 21A towards Massachusetts Turnpike | 0.4 mi | |
| Continue straight | 0.7 mi | |
| Continue onto New York State Thruway Berkshire Connector | 17.3 mi | |
| Merge left onto New York State Thruway Berkshire Connector (I 90 E) | 6.6 mi | |
| Continue onto Massachusetts Turnpike (I 90 E) | 89.6 mi | |
| Take exit 10 towards I 395: Auburn | 0.3 mi | |
| Keep left at the fork | 0.7 mi | |
| Continue onto I 290 E | 20.1 mi | |
| Keep left towards I 495 North: Lowell | 0.7 mi | |
| Merge left onto I 495 N | 55.6 mi | |
| Merge left onto I 95 N | 60.8 mi | |
| Keep right towards South Portland | 52.6 mi | |
| Merge left onto Maine Turnpike (I 95 N) | 79.1 mi | |
| Take exit 182A towards I 395 South: Bangor | 0.4 mi | |
| Merge left onto I 395 W | 1.6 mi | |
| Take exit 4 towards ME 15 South: South Main Street | 900 feet | |
| Keep right towards ME 15 South: South Main Street | 500 feet | |
| Go straight onto South Main Street (ME 15) | 4.8 mi | |
| Continue onto Main Road (ME 9) | 7.6 mi | |
| Continue onto Airline Road (ME 9) | 80.5 mi | |
| Enter the roundabout and take the 2nd exit onto International Avenue | 200 feet | |
| Exit the roundabout onto International Avenue | 0.7 mi | |
| Keep left onto 1 | 400 feet | |
| Merge left onto Lane 5 (1) | 67.2 mi | |
| Continue onto Saint John Throughway (1) | 5.4 mi | |
| Continue onto Harbour Bridge (1) | 0.8 mi | |
| Take the ramp towards Saint John Center | 0.3 mi | |
| Go straight onto Main Street (100) | 500 feet | |
| You have arrived at your destination, on the right |
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Dearborn, Michigan - Saint John, New Brunswick