I 10, US 281 $south
530.3 mi8 hours 20 mins
| Head east on Thompson Street (Loop 210) | 100 feet | |
| Turn right onto South Temple Drive (US 59 S) | 68.9 mi | |
| Keep left onto Eastex Freeway (I 69 S) | 9.8 mi | |
| Take the ramp towards Grand Parkway | 0.3 mi | |
| Merge right onto Eastex Freeway Frontage Road | 1.4 mi | |
| Turn right onto North Grand Parkway East Frontage Road | 0.9 mi | |
| Continue straight | 0.3 mi | |
| Merge left onto North Grand Parkway East (TX 99 Toll) | 8.9 mi | |
| Keep right onto North Grand Parkway East (TX 99 Toll) | 15.9 mi | |
| Continue onto Toll 99 | 1.0 mi | |
| Continue onto North Grand Parkway West (TX 99 Toll) | 24.2 mi | |
| Take the ramp towards I 10 | 0.3 mi | |
| Merge right onto West Grand Parkway North Frontage Road | 1.3 mi | |
| Turn right onto Katy Freeway Frontage Road | 0.8 mi | |
| Take the ramp on the left towards I 10 West | 0.3 mi | |
| Merge left onto Katy Freeway (I 10) | 160.7 mi | |
| Take the ramp towards I 410 | 0.3 mi | |
| Keep left towards I 410 | 0.2 mi | |
| Keep right towards I 410 South | 0.3 mi | |
| Keep left onto TX 130 S | 0.3 mi | |
| Merge left onto Connally Loop (I 410 S) | 7.0 mi | |
| Take the ramp towards I 37: San Antonio | 0.2 mi | |
| Keep left towards I 37 South: Corpus Christi | 0.5 mi | |
| Merge left onto I 37 S | 60.6 mi | |
| Take the ramp towards US 281 South | 0.5 mi | |
| Continue onto US 281 S | 95.0 mi | |
| Take the ramp | 0.3 mi | |
| Continue onto Fallifurias Expressway (US 281 S) | 68.3 mi | |
| Take the ramp towards US 281 South: Pharr | 1.6 mi | |
| Turn left onto US 83-S Business | 100 feet | |
| You have arrived at your destination |
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Diboll, Texas - Pharr, Texas