I 80, I 99 $south; US 220 $south
81.2 mi1 hour 32 mins
| Head southeast on West Long Avenue | 500 feet | |
| Turn left onto North Brady Street (US 219) | 700 feet | |
| Continue slightly left onto Liberty Boulevard (US 219) | 0.6 mi | |
| Turn right onto East Dubois Avenue (PA 255) | 1.4 mi | |
| Continue onto Bee Line Highway (PA 255) | 1.1 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 80 | 21.5 mi | |
| Take the ramp towards PA 970 to US 322: Woodland | 0.3 mi | |
| Go straight onto Shawville Highway (PA 970) | 1.4 mi | |
| Turn left onto Woodland Bigler Highway (US 322) | 2.8 mi | |
| Continue onto Philipsburg Bigler Highway (US 322) | 7.1 mi | |
| Continue onto North Front Street (US 322) | 0.3 mi | |
| Continue onto North Centre Street (US 322) | 800 feet | |
| Turn left onto Railroad Street (US 322) | 1.0 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.5 mi | |
| Continue onto Upper Flat Rock Road (US 322) | 1.6 mi | |
| Continue onto Flat Rock Road (US 322) | 1.5 mi | |
| Continue onto 28th Division Highway (US 322 E) | 0.3 mi | |
| Take the ramp towards US 220 Alternate: Port Matilda | 0.2 mi | |
| Continue onto North High Street | 0.6 mi | |
| Take the ramp on the right towards I 99 South: Altoona | 0.4 mi | |
| Merge left onto I 99 S | 12.9 mi | |
| Take the ramp towards PA 453: Tyrone | 0.4 mi | |
| Turn left onto Birmingham Pike (PA 453) | 9.0 mi | |
| Turn right onto William Penn Highway (US 22 W) | 5.2 mi | |
| Turn left onto Yellow Spring Drive | 3.7 mi | |
| Continue onto High Street | 0.6 mi | |
| Turn right onto West 1st Street (PA 866) | 300 feet | |
| You have arrived at your destination |
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DuBois, Pennsylvania - Williamsburg, Pennsylvania