US 19 $south, I 77 $south
337.2 mi5 hours 35 mins
| Head south on Villanova Road | 200 feet | |
| Turn right onto County Route 13/10 | 400 feet | |
| Turn right onto WV 4 | 0.3 mi | |
| Turn left onto Servia Road (County Route 11) | 2.4 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 79 N | 10.6 mi | |
| Take the ramp towards US 19 South: Beckley | 0.3 mi | |
| Keep right at the fork | 200 feet | |
| Merge left onto US 19 | 68.6 mi | |
| Keep left towards I 64 East: Bluefield | 1.1 mi | |
| Merge left onto West Virginia Turnpike (I 64 E) | 46.3 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 8.7 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 37.3 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 30.7 mi | |
| Take the ramp towards I 40 Business East: Kernersville | 800 feet | |
| Merge left onto I 40 Business E | 2.0 mi | |
| Continue onto I 40 Business E | 11.2 mi | |
| Merge left onto I 40 | 4.8 mi | |
| Keep right onto I 40 | 7.8 mi | |
| Merge right onto I 40 | 1.8 mi | |
| Keep left onto I 40 | 34.5 mi | |
| Take the ramp | 0.3 mi | |
| Keep right at the fork | 0.2 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto I 85 US 70 Connector (NC 86 Truck) | 3.7 mi | |
| Make a sharp left onto NC 86 | 0.4 mi | |
| Turn right onto NC 57 | 8.6 mi | |
| Turn left onto Guess Road (NC 157) | 6.4 mi | |
| Turn right onto Hurdle Mills Road (NC 157) | 8.2 mi | |
| Continue onto South Main Street (NC 157) | 0.4 mi | |
| Turn left onto Durham Road (US 158) | 300 feet | |
| Continue onto South Madison Boulevard (US 158) | 0.7 mi | |
| Turn right onto Gordon Street | 200 feet | |
| You have arrived at your destination, on the right |
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Duck, WV, USA - Roxboro, NC, USA