I 95 $south, I 40
411.4 mi6 hours 27 mins
| Head south on North Court Street | 500 feet | |
| Turn right onto West Patrick Street (MD 144) | 0.5 mi | |
| Keep left onto South Jefferson Street | 0.8 mi | |
| Take the ramp towards US 40 East | 700 feet | |
| Merge left onto Frederick Freeway (US 40) | 1.0 mi | |
| Continue onto Eisenhower Memorial Highway (I 270 N) | 22.9 mi | |
| Keep right onto I 270 S | 0.3 mi | |
| Continue onto I 270 N | 6.4 mi | |
| Keep right towards I 270 Spur: Washington | 2.0 mi | |
| Merge right onto Capital Beltway (I 495 W) | 1.2 mi | |
| Keep left onto Capital Beltway (I 495 W) | 4.7 mi | |
| Keep right onto Capital Beltway (I 495 S) | 11.3 mi | |
| Take the ramp towards I 95 South: Richmond | 0.5 mi | |
| Keep left at the fork | 0.3 mi | |
| Keep left towards I 95 South: Richmond | 0.4 mi | |
| Merge left onto Henry G. Shirley Memorial Highway (I 395 S) | 58.7 mi | |
| Continue onto I 95 S | 25.7 mi | |
| Take the ramp on the left towards I 295 South: Rocky Mount NC | 1.8 mi | |
| Merge right onto I 295 | 42.4 mi | |
| Merge right towards I 95 South: Emporia | 108.0 mi | |
| Take the ramp towards US 264: Zebulon | 0.2 mi | |
| Keep left towards I 795 East | 0.4 mi | |
| Keep right towards I 795 East | 0.2 mi | |
| Continue slightly right onto I 795 E | 4.5 mi | |
| Keep right onto I 795 S | 21.7 mi | |
| Continue onto NC 581 | 3.8 mi | |
| Continue onto US 13 S | 19.3 mi | |
| Turn left | 0.3 mi | |
| Merge left onto I 40 | 64.7 mi | |
| Continue onto North College Road (US 117) | 1.2 mi | |
| Turn right onto Martin Luther King Jr Parkway (US 74) | 4.7 mi | |
| Continue onto North 3rd Street | 1.1 mi | |
| You have arrived at your destination |
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Frederick, Maryland - Wilmington, North Carolina