MO 6, I 49 $south; US 71 $south
277.0 mi4 hours 23 mins
| Head north on North West Border Street | 600 feet | |
| Turn left onto Sherman Street | 700 feet | |
| Turn right onto Mc Kinley Street | 700 feet | |
| Turn left onto MO 6 | 13.6 mi | |
| Turn left onto Highway 6 (MO 6) | 29.4 mi | |
| Continue onto 2nd Street (MO 6) | 1.5 mi | |
| Continue onto US 69 | 4.4 mi | |
| Take the ramp on the left | 900 feet | |
| Merge left onto I 35 S | 46.6 mi | |
| Keep left onto Chicago-Kansas City Expressway (I 35 S) | 1.5 mi | |
| Take exit 12 towards I 435 South: Saint Louis | 0.7 mi | |
| Merge left onto I 435 | 9.6 mi | |
| Keep left onto Lamar Hunt Memorial Highway (I 435) | 8.9 mi | |
| Take exit 71 towards I 49 South: Joplin | 0.7 mi | |
| Keep left at the fork | 800 feet | |
| Keep left towards I 49 South: Joplin | 0.3 mi | |
| Merge left onto I 49 S | 24.7 mi | |
| Keep left onto I 49 S | 105.3 mi | |
| Take exit 53 towards I 49 Business: Webb City | 800 feet | |
| Turn right onto I 49 Business | 1.4 mi | |
| Keep left onto I 49 Business | 5.3 mi | |
| Keep left towards MO 249 South: Joplin | 6.2 mi | |
| Continue onto I 49 S | 12.0 mi | |
| Take the ramp towards I 49 Business: Racine | 0.3 mi | |
| Turn left onto I 49 Business | 2.8 mi | |
| Turn left onto West Harmony Street (MO 86) | 0.4 mi | |
| Turn right onto South Neosho Boulevard (US 60 Business) | 0.8 mi | |
| You have arrived at your destination |
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Galt, Missouri - Neosho, Missouri