I 65 $south, I 75 $south
843.1 mi13 hours 28 mins
| Head north on Center Drive | 200 feet | |
| Turn right onto East Higgins Road (IL 72) | 1.7 mi | |
| Turn right onto Randall Road (CR 34) | 1.7 mi | |
| Turn left towards I 90 East: Chicago | 0.3 mi | |
| Merge left onto Jane Addams Memorial Tollway (I 90 E) | 25.5 mi | |
| Keep left onto Jane Addams Memorial Tollway (I 90 E) | 1.0 mi | |
| Merge right onto Kennedy Expressway (I 90) | 5.6 mi | |
| Keep right onto Kennedy Expressway (I 90) | 8.3 mi | |
| Continue onto Dan Ryan Expressway (I 90) | 2.4 mi | |
| Keep left towards I 90 Express | 3.8 mi | |
| Take the ramp towards I 90 East: Chicago Skyway | 0.4 mi | |
| Merge right onto Dan Ryan Expressway (I 90) | 0.5 mi | |
| Keep left towards I 90 East: Chicago Skyway | 10.6 mi | |
| Keep left onto Indiana Toll Road (I 90) | 11.3 mi | |
| Take the ramp towards IN 53 | 0.3 mi | |
| Turn right onto Broadway (SR 53) | 0.2 mi | |
| Turn left onto East 5th Avenue (US 12) | 1.6 mi | |
| Turn right onto I 65 S | 132.7 mi | |
| Keep left onto I 65 S | 130.0 mi | |
| Take the ramp towards I 64: Lexington | 100 feet | |
| Keep left towards I 64 East: Lexington | 0.8 mi | |
| Merge left onto I 64 E | 175.4 mi | |
| Continue onto I 75 S | 64.6 mi | |
| Continue onto I 275 S | 0.3 mi | |
| Take the ramp towards I 640 East: Asheville | 0.2 mi | |
| Merge left onto I 640 E | 6.7 mi | |
| Keep left towards I 40 East: Asheville | 28.5 mi | |
| Keep right towards I 40 East: Asheville | 76.3 mi | |
| Take the ramp towards I 26 East: Hendersonville | 13.3 mi | |
| Continue onto I 26 E | 134.6 mi | |
| Keep left towards I 126: Columbia | 3.4 mi | |
| Take the ramp | 0.3 mi | |
| Continue onto Huger Street (US 21) | 0.6 mi | |
| Make a U-turn and continue on Huger Street (US 21) | 100 feet | |
| You have arrived at your destination, on the left |
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Gilberts, Illinois - Columbia, South Carolina