I 80, I 35 $south
640.1 mi9 hours 45 mins
| Head northeast on CTH V | 0.6 mi | |
| Take the ramp on the right | 26.8 mi | |
| Keep right towards I 41: Beloit | 5.4 mi | |
| Take exit 4 on the left towards I 43 South: Beloit | 60.6 mi | |
| Take exit 1A towards I 90 East: Chicago | 0.3 mi | |
| Merge left onto I 39 S | 19.7 mi | |
| Take the ramp towards I 39: Bloomington | 0.8 mi | |
| Continue onto I 39 S | 2.2 mi | |
| Take the ramp towards I 39: Bloomington | 22.3 mi | |
| Take exit 97B towards I 88 West Toll: Moline | 0.6 mi | |
| Merge left onto Ronald Reagan Memorial Tollway (I 88 W) | 21.5 mi | |
| Keep left onto Ronald Reagan Memorial Tollway (I 88 W) | 12.3 mi | |
| Continue onto Ronald Reagan Memorial Highway (I 88 W) | 38.9 mi | |
| Continue onto I 88 W | 4.6 mi | |
| Take the ramp towards I 80: Des Moines | 0.4 mi | |
| Keep right at the fork | 0.7 mi | |
| Merge left onto I 80 | 323.6 mi | |
| Continue onto I 35 S | 34.5 mi | |
| Keep left onto Chicago-Kansas City Expressway (I 35 S) | 1.5 mi | |
| Take exit 12 towards I 435 South: Saint Louis | 0.7 mi | |
| Merge left onto I 435 | 9.6 mi | |
| Keep left onto Lamar Hunt Memorial Highway (I 435) | 8.9 mi | |
| Take exit 71 towards I 49 South: Joplin | 0.7 mi | |
| Keep left at the fork | 800 feet | |
| Keep left towards I 49 South: Joplin | 0.3 mi | |
| Merge left onto I 49 S | 24.7 mi | |
| Keep left onto I 49 S | 17.0 mi | |
| Take the ramp | 0.2 mi | |
| Turn right onto East 1st Street (MO 18) | 700 feet | |
| Turn right onto Old US Highway 71 (MO 18) | 0.2 mi | |
| Turn left onto East Main Street (MO 18) | 0.5 mi | |
| You have arrived at your destination |
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Grafton, Wisconsin - Adrian, Missouri