Dwight D. Eisenhower Highway, I 64 $east
1,849.1 mi1 day 3 hours 52 mins
| Head north on North 5th Street | 0.6 mi | |
| Turn right onto North Avenue (US 6 E) | 1,000 feet | |
| Turn left onto North 7th Street | 1.0 mi | |
| Continue onto 26 1/2 Road (26½) | 0.3 mi | |
| Turn right onto Horizon Drive | 0.7 mi | |
| Enter the roundabout and take the 2nd exit onto Horizon Drive | 100 feet | |
| Exit the roundabout onto Horizon Drive | 0.9 mi | |
| Take the ramp on the right towards I 70 | 0.2 mi | |
| Merge left onto I 70 E | 245.5 mi | |
| Keep left onto I 70 E | 172.7 mi | |
| Continue onto I 70 | 354.4 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 142.4 mi | |
| Keep right onto I 70 E | 8.0 mi | |
| Take the ramp towards I 64 East: Louisville | 0.6 mi | |
| Merge left onto I 64 E | 70.1 mi | |
| Keep right towards I 57 South | 4.6 mi | |
| Take the ramp on the left towards I 64 East: Louisville | 257.0 mi | |
| Take exit 111 on the left towards I 64 East: Winchester | 16.6 mi | |
| Keep left onto I 64 E | 252.8 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 8.7 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 37.3 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 30.7 mi | |
| Take the ramp towards I 40 Business East: Kernersville | 800 feet | |
| Merge left onto I 40 Business E | 2.0 mi | |
| Continue onto I 40 Business E | 11.2 mi | |
| Merge left onto I 40 | 4.8 mi | |
| Keep right onto I 40 | 6.7 mi | |
| Take the ramp towards US 220 North | 0.2 mi | |
| Merge left onto Freeman Mill Road | 2.0 mi | |
| Go straight onto Randleman Road | 400 feet | |
| Merge left onto Freeman Mill Road | 0.7 mi | |
| Take the ramp towards McGee Street | 500 feet | |
| You have arrived at your destination |
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Grand Junction, Colorado - Greensboro, North Carolina