US 158, Old Franklin Turnpike
146.9 mi2 hours 57 mins
| Head southwest on North Garnett Street (US 1 Business) | 300 feet | |
| Turn right onto West Andrews Avenue (NC 39) | 1.1 mi | |
| Take the ramp on the right | 900 feet | |
| Merge left onto I 85 S | 7.7 mi | |
| Take the ramp towards US 158: Oxford | 0.3 mi | |
| Turn right onto US 158 W | 2.7 mi | |
| Turn right onto College Street (US 15) | 0.8 mi | |
| Turn left onto Roxboro Road (US 158 Business) | 23.2 mi | |
| Turn right onto US 158 | 0.6 mi | |
| Keep left at the fork | 100 feet | |
| Turn right onto Durham Road (US 158) | 0.5 mi | |
| Continue onto South Madison Boulevard (US 158) | 0.6 mi | |
| Turn left onto US 158 | 1,000 feet | |
| Turn left onto Leasburg Road (US 158) | 900 feet | |
| Turn right onto Concord Road (NC 57) | 0.2 mi | |
| Continue onto Semora Road (NC 57) | 17.2 mi | |
| Continue onto Milton Highway (NC 62) | 4.3 mi | |
| Turn left onto South Boston Highway (US 58) | 2.3 mi | |
| Continue onto South Boston Road (US 58) | 2.9 mi | |
| Take the ramp towards US 29 North | 0.4 mi | |
| Merge left onto Danville Expressway (US 29) | 27.3 mi | |
| Take the ramp towards VA 40 | 0.2 mi | |
| Turn left onto West Gretna Road (VA 40) | 13.6 mi | |
| Continue onto Old Franklin Turnpike (VA 40) | 16.4 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto Virgil H Goode Highway (US 220 N) | 22.9 mi | |
| Take the ramp towards US 221: Vinton | 700 feet | |
| Turn left onto Elm Avenue Southeast (VA 24) | 0.3 mi | |
| Turn right onto South Jefferson Street (VA 116) | 0.3 mi | |
| You have arrived at your destination |
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Henderson, North Carolina - Roanoke, Virginia