I 81 $north, New York State Thruway
397.4 mi6 hours 32 mins
| Head north on Carlton Avenue | 800 feet | |
| Turn left onto Fulton Street | 0.6 mi | |
| Turn right onto Flatbush Avenue Extension | 0.6 mi | |
| Continue onto Manhattan Bridge lower level | 1.3 mi | |
| Keep left onto Manhattan Bridge lower level | 300 feet | |
| Continue onto Canal Street | 0.8 mi | |
| Take the ramp on the right towards I 78: Holland Tunnel | 400 feet | |
| Continue slightly left onto Holland Tunnel access | 1.7 mi | |
| Continue onto 14th Street | 0.5 mi | |
| Keep left onto 14th Street Viaduct (NJ 139) | 0.4 mi | |
| Continue onto Route 139 (Lower Level) Westbound (NJ 139) | 0.7 mi | |
| Continue onto Pulaski Skyway (NJ 139) | 600 feet | |
| Take the ramp towards US 1-9: Newark | 0.5 mi | |
| Continue onto US 1-9 Truck (US 1 Truck) | 0.7 mi | |
| Keep right onto NJ 7 | 1.3 mi | |
| Keep left onto Newark Turnpike (CR 508) | 2.7 mi | |
| Continue onto Harrison Avenue (CR 508) | 0.8 mi | |
| Turn right onto North 2nd Street | 100 feet | |
| Continue straight to stay on North 2nd Street | 100 feet | |
| Take the ramp on the left | 0.2 mi | |
| Merge right onto I 280 W | 14.0 mi | |
| Keep left at the fork | 0.5 mi | |
| Merge right onto I 80 W | 46.2 mi | |
| Keep straight at the fork | 900 feet | |
| Merge right onto I 80 | 5.3 mi | |
| Keep left onto I 80 | 11.9 mi | |
| Take the ramp towards I 380 North: Scranton | 0.7 mi | |
| Continue onto I 380 N | 27.1 mi | |
| Keep right towards I 81 North: Binghamton | 0.3 mi | |
| Keep left towards I 81 North: Binghamton | 0.3 mi | |
| Merge left onto I 81 N | 53.6 mi | |
| Continue onto I 81 W | 4.5 mi | |
| Keep right towards I 81 North: Syracuse | 1.8 mi | |
| Keep left towards I 81 North: Syracuse | 70.1 mi | |
| Take the ramp towards I 690 West: Fairgrounds | 0.2 mi | |
| Merge right towards Fairgrounds | 8.6 mi | |
| Take the ramp towards I 90 | 0.2 mi | |
| Keep left towards I 90 | 0.5 mi | |
| Keep right towards I 90 West: Buffalo | 1,000 feet | |
| Merge left onto New York State Thruway (I 90 W) | 131.2 mi | |
| Take exit 51W towards NY 33 West: Buffalo | 800 feet | |
| Continue towards NY 33 West: Buffalo | 0.2 mi | |
| Merge left onto Kensington Expressway (NY 33) | 5.8 mi | |
| Take the ramp towards Jefferson Avenue | 800 feet | |
| Turn left onto Jefferson Avenue | 0.3 mi | |
| Turn left onto Sycamore Street | 300 feet | |
| Turn right onto Madison Street | 900 feet | |
| You have arrived at your destination |
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New York, NY, USA - Buffalo, NY, USA