I 24 $west, I 70 $west; US 40 $west
743.9 mi11 hours 27 mins
| Head northwest on Madison Street | 100 feet | |
| Turn right onto South Side Square | 400 feet | |
| Turn left onto East Side Square | 400 feet | |
| Continue onto Washington Street Southeast | 400 feet | |
| Continue onto Washington Street Northeast | 0.6 mi | |
| Turn left onto Pratt Avenue Northeast | 0.3 mi | |
| Continue onto University Drive Northwest | 1.9 mi | |
| Make a slight right | 200 feet | |
| Turn right onto Jordan Lane Northwest (SR 53) | 2.3 mi | |
| Continue onto Ardmore Hwy (SR 53) | 5.9 mi | |
| Continue onto Ardmore Highway (SR 53) | 16.2 mi | |
| Continue onto SR 7 | 0.4 mi | |
| Take the ramp on the right towards Nashville | 0.2 mi | |
| Merge left onto I 65 N | 51.6 mi | |
| Keep left onto I 65 N | 29.3 mi | |
| Keep right towards Knoxville | 0.3 mi | |
| Merge left onto I 40 | 700 feet | |
| Continue towards I 24 West: Clarksville | 0.5 mi | |
| Keep left towards I 24 West: Clarksville | 0.4 mi | |
| Merge right onto I 24 W | 2.3 mi | |
| Keep right towards I 24 West: Clarksville | 2.1 mi | |
| Keep left towards I 24 West: Clarksville | 112.6 mi | |
| Keep right onto I 24 W | 63.5 mi | |
| Keep left towards I 57 North: Chicago | 0.4 mi | |
| Merge left towards Mount Vernon | 51.7 mi | |
| Take the ramp on the left towards I 64 West: Saint Louis | 70.7 mi | |
| Take the ramp towards I 70 West: Kansas City | 0.7 mi | |
| Merge right onto I 70 W | 248.8 mi | |
| Keep right towards I 70 West: Saint Joseph | 0.8 mi | |
| Keep right towards I 29 North: Saint Joseph | 4.6 mi | |
| Keep left towards I 29 North: K.C.I. Airport | 14.2 mi | |
| Merge left onto I 29 N | 2.7 mi | |
| Keep left towards I 29 North: Saint Joseph | 37.2 mi | |
| Continue onto I 29 N | 13.3 mi | |
| Take the ramp towards US 59: Oregon | 0.2 mi | |
| Turn left onto Ventura Drive (US 59) | 7.5 mi | |
| You have arrived at your destination |
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Huntsville, Alabama - Oregon, Missouri