How to get from Indianapolis, Indiana to Knoxville, Tennessee

Discover, print or download the driving directions for the best route to go from Indianapolis, Indiana to Knoxville, Tennessee.

Enlarge the route map Indianapolis, Indiana - Knoxville, Tennessee

Driving directions from Indianapolis, Indiana to Knoxville, Tennessee

I 74 $east; US 421 $south, I 75 $south

349.5 mi5 hours 35 mins

Head west on East Washington Street 200 feet
Turn right onto North New Jersey Street 500 feet
Turn right onto East Market Street 500 feet
Turn right onto North East Street 500 feet
Turn left onto East Washington Street 0.4 mi
Turn right onto Southeastern Avenue 5.0 mi
Continue onto [Southeastern Avenue Connector] 1.0 mi
Continue onto I 74 E 69.6 mi
Take exit 164 towards SR 1: Saint Leon 0.2 mi
Turn right onto SR 1 14.2 mi
Turn right to stay on SR 1 600 feet
Turn left onto Belleview Drive (SR 1) 0.3 mi
Continue towards I 275: Ohio 0.4 mi
Keep right towards I 275 South: Kentucky 0.5 mi
Merge left onto I 275 S 0.6 mi
Continue onto Carroll Lee Cropper Bridge (I 275 E) 13.5 mi
Take exit 84 towards I 71: Cincinnati 0.3 mi
Keep right towards I 71 South: Lexington 0.7 mi
Keep left towards I 71 South: Lexington 0.3 mi
Keep left at the fork 0.7 mi
Merge left onto I 71 S 237.1 mi
Continue onto I 275 S 2.9 mi
Keep right towards I 40 East: Asheville 0.3 mi
Keep right at the fork 600 feet
Keep left at the fork 0.5 mi
Go straight onto Henley Street (US 11) 0.2 mi
You have arrived at your destination

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Indianapolis, Indiana - Knoxville, Tennessee

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