I 74 $east; US 421 $south, I 75 $south
382.2 mi6 hours 12 mins
| Head south on North Pennsylvania Street | 0.2 mi | |
| Turn left onto East Maryland Street | 0.3 mi | |
| Continue onto East Washington Street | 0.5 mi | |
| Turn right onto Southeastern Avenue | 5.0 mi | |
| Continue onto [Southeastern Avenue Connector] | 1.0 mi | |
| Continue onto I 74 E | 69.6 mi | |
| Take exit 164 towards SR 1: Saint Leon | 0.2 mi | |
| Turn right onto SR 1 | 14.2 mi | |
| Turn right to stay on SR 1 | 600 feet | |
| Turn left onto Belleview Drive (SR 1) | 0.3 mi | |
| Continue towards I 275: Ohio | 0.4 mi | |
| Keep right towards I 275 South: Kentucky | 0.5 mi | |
| Merge left onto I 275 S | 0.6 mi | |
| Continue onto Carroll Lee Cropper Bridge (I 275 E) | 13.5 mi | |
| Take exit 84 towards I 71: Cincinnati | 0.3 mi | |
| Keep right towards I 71 South: Lexington | 0.7 mi | |
| Keep left towards I 71 South: Lexington | 0.3 mi | |
| Keep left at the fork | 0.7 mi | |
| Merge left onto I 71 S | 237.1 mi | |
| Continue onto I 275 S | 0.3 mi | |
| Take the ramp towards I 640 East: Asheville | 0.2 mi | |
| Merge left onto I 640 E | 6.7 mi | |
| Keep left towards I 40 East: Asheville | 14.5 mi | |
| Take the ramp towards SR 66: Sevierville | 900 feet | |
| Keep right towards SR 66: Sevierville | 600 feet | |
| Merge left onto Winfield Dunn Parkway (TN 66) | 8.4 mi | |
| Continue onto Forks of the River Parkway (US 441) | 0.6 mi | |
| Turn right onto Parkway | 5.1 mi | |
| Take the ramp on the left towards Jake Thomas Road | 100 feet | |
| Turn left onto Jake Thomas Road | 300 feet | |
| Turn right onto North River Road | 0.2 mi | |
| You have arrived at your destination | 0 feet |
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Indianapolis, Indiana - Pigeon Forge, Tennessee