I 75 $north, Highway 401
502.4 mi8 hours 6 mins
| Head west on East Washington Street | 200 feet | |
| Turn right onto North New Jersey Street | 800 feet | |
| Turn right onto East Wabash Street | 300 feet | |
| Turn left onto North Cleveland Street | 800 feet | |
| Turn right onto East New York Street | 0.4 mi | |
| Turn left onto North Pine Street | 0.2 mi | |
| Take the ramp | 100 feet | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto I 70 | 106.9 mi | |
| Take the ramp towards I 75 North: Toledo | 0.7 mi | |
| Merge left onto I 75 N | 130.4 mi | |
| Keep right towards I 75 North: Toledo | 9.4 mi | |
| Take exit 201B towards SR 25 North: Downtown | 0.7 mi | |
| Merge right onto Anthony Wayne Trail (SR 25) | 600 feet | |
| Continue slightly left onto South Erie Street (SR 25) | 0.9 mi | |
| Turn left onto Cherry Street (SR 25) | 0.2 mi | |
| Turn right onto Greenbelt Parkway (SR 25) | 1.4 mi | |
| Take the ramp towards I 280 North | 0.4 mi | |
| Merge left onto I 280 N | 0.8 mi | |
| Keep right towards I 75 North: Detroit | 0.6 mi | |
| Continue slightly right onto I 75 N | 51.0 mi | |
| Take exit 47B towards Bridge to Canada | 0.4 mi | |
| Turn right | 0.2 mi | |
| Keep right at the fork | 300 feet | |
| Take the ramp on the right | 0.3 mi | |
| Continue onto Ambassador Bridge | 1.2 mi | |
| Keep right at the fork | 100 feet | |
| Keep straight at the fork | 600 feet | |
| Take the ramp on the right | 300 feet | |
| Continue onto Huron Church Road (3) | 3.9 mi | |
| Continue onto Talbot Road (3) | 0.2 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto Rt. Hon. Herb Gray Parkway (401 E) | 2.1 mi | |
| Continue onto Macdonald–Cartier Freeway (401 E) | 1.4 mi | |
| Continue onto Highway 401 (401 E) | 137.2 mi | |
| Keep right towards 403: Brantford | 46.3 mi | |
| Take the ramp on the left towards 6 North: Guelph | 0.3 mi | |
| Continue onto Highway 6 (6) | 1.6 mi | |
| Turn right onto Dundas Street East (5) | 1.2 mi | |
| Turn left onto Riley Street | 0.7 mi | |
| Turn left onto Rockhaven Lane | 0 feet | |
| You have arrived at your destination |
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Indianapolis, Indiana - Waterdown, Hamilton, Ontario