I 99 $south; US 220 $south, William Penn Highway
303.8 mi5 hours 27 mins
| Head west on East Seneca Street (NY 79) | 0.9 mi | |
| Make a slight right onto West State Street (NY 79) | 700 feet | |
| Turn left onto Floral Avenue (NY 13A) | 0.9 mi | |
| Continue onto Five Mile Drive (NY 13A) | 1.1 mi | |
| Turn right onto Elmira Road (NY 13) | 1.5 mi | |
| Make a slight right to stay on Elmira Road (NY 13) | 4.0 mi | |
| Enter the roundabout and take the 2nd exit | 100 feet | |
| Exit the roundabout | 200 feet | |
| Go straight onto Elmira Road (NY 13) | 6.6 mi | |
| Continue onto State Highway 13 (NY 13) | 8.3 mi | |
| Continue onto Old Sullivanville Road (NY 13) | 4.6 mi | |
| Keep right towards I 86 West: Corning | 500 feet | |
| Keep left towards I 86 West: Corning | 0.2 mi | |
| Merge left onto Southern Tier Expressway (I 86 W) | 16.9 mi | |
| Take exit 44A towards I 99 South: Williamsport | 0.6 mi | |
| Keep left towards I 99 South: Williamsport | 0.2 mi | |
| Continue onto I 99 S | 73.1 mi | |
| Take the ramp towards US 220 South: Lock Haven | 0.5 mi | |
| Merge left onto Susquehanna Beltway (US 220 S) | 11.3 mi | |
| Continue onto Appalachian Thruway (US 220 S) | 15.9 mi | |
| Take exit 107 towards PA 477: Salona | 0.2 mi | |
| Turn right onto PA 477 | 400 feet | |
| Turn left onto Fernberg Road (PA 64) | 0.4 mi | |
| Continue onto Nittany Valley Drive (PA 64) | 4.0 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 80 S | 11.8 mi | |
| Take the ramp towards I-99 south : Bellefonte | 0.3 mi | |
| Turn left onto Jacksonville Road (US 220) | 1.0 mi | |
| Continue onto I 99 S | 23.2 mi | |
| Keep left onto I 99 S | 33.8 mi | |
| Take the ramp towards US 22: Ebensburg | 1.4 mi | |
| Continue onto William Penn Highway (US 22 W) | 16.4 mi | |
| Continue onto Admiral Peary Highway (US 22 W) | 13.4 mi | |
| Continue onto William Penn Highway (US 22 W) | 41.4 mi | |
| Make a sharp right onto Vincent Hall Road | 500 feet | |
| Continue onto Sardis Road | 600 feet | |
| Turn left onto Logan Ferry Road | 100 feet | |
| Turn right to stay on Logan Ferry Road | 1.1 mi | |
| Continue onto Old Frankstown Road | 0.5 mi | |
| Continue onto New Texas Road | 2.7 mi | |
| Turn left onto Saltsburg Road (PA 380) | 1.2 mi | |
| Turn right onto Unity Center Road | 1.8 mi | |
| Turn left onto Leechburg Road | 0.3 mi | |
| Continue onto Milltown Road | 0.9 mi | |
| Turn left onto Hulton Road | 0.4 mi | |
| You have arrived at your destination |
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Ithaca, New York - Newfield, Pennsylvania