US 72, I 40
417.0 mi6 hours 55 mins
| Head west on West Eastport Street | 300 feet | |
| Turn left onto South Pearl Street | 0.2 mi | |
| Turn right onto West Quitman Street (MS 172) | 0.4 mi | |
| Turn left onto Battleground Drive | 1.0 mi | |
| Turn left onto Veterans Memorial Drive (MS 25) | 0.3 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto US 72 | 78.2 mi | |
| Keep left onto US 72 | 8.4 mi | |
| Take the ramp on the left towards Memphis | 0.4 mi | |
| Merge left onto Bill Morris Parkway (TN 385 W) | 13.8 mi | |
| Keep left towards I 240 West: Jackson Miss | 1.0 mi | |
| Merge right onto I 240 W | 8.2 mi | |
| Continue onto I 55 N | 5.5 mi | |
| Take the ramp towards I 55 North: Saint Louis | 7.9 mi | |
| Keep left onto I 40 | 242.1 mi | |
| Take the ramp towards Ozark | 0.3 mi | |
| Turn right onto AR 23 | 5.0 mi | |
| Make a slight left onto AR 23 | 3.6 mi | |
| Turn left onto AR 23 | 8.0 mi | |
| Continue onto Hwy 23 | 5.9 mi | |
| Continue onto AR 23 | 2.1 mi | |
| Go straight onto AR 16 | 20.0 mi | |
| Continue onto Hwy 23 | 4.5 mi | |
| Turn left onto East War Eagle Avenue (US 412B) | 100 feet | |
| You have arrived at your destination |
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Iuka, Mississippi - Huntsville, Arkansas