I 65 $north, I 71 $north
689.9 mi10 hours 51 mins
| Head south on South Highland Avenue (US 45) | 800 feet | |
| Keep left onto East Sycamore Street (US 70) | 600 feet | |
| Continue onto South Cumberland Street (US 70) | 600 feet | |
| Merge left onto East Chester Street (US 70) | 5.6 mi | |
| Continue onto Christmasville Road | 0.2 mi | |
| Take the ramp | 0.5 mi | |
| Merge left onto I 40 | 120.4 mi | |
| Keep left onto I 40 | 1.9 mi | |
| Take the ramp on the left towards I 65 North: Louisville | 0.4 mi | |
| Merge right onto I 65 N | 1.7 mi | |
| Keep left towards I 24 West: Clarksville | 2.1 mi | |
| Keep right towards I 65 North: Louisville | 7.1 mi | |
| Keep left onto I 65 N | 156.2 mi | |
| Take the ramp towards I 264: Louisville International Airport | 0.5 mi | |
| Keep right towards I 264 East: Watterson Expressway | 0.8 mi | |
| Merge left onto Henry Watterson Expressway (I 264 E) | 10.0 mi | |
| Keep right towards I 71 North: Cincinnati | 0.4 mi | |
| Merge left onto I 71 N | 71.0 mi | |
| Keep left towards I 71 North: Cincinnati | 19.7 mi | |
| Keep right towards I 71 North: Columbus | 32.1 mi | |
| Take exit 32 towards SR 123: Morrow | 0.3 mi | |
| Turn right onto SR 123 | 500 feet | |
| Turn left onto SR 350 | 4.3 mi | |
| Turn left onto Middleboro Road (C-45) | 1.9 mi | |
| Turn left onto Wilmington Road (SR 350 Truck) | 300 feet | |
| Take the ramp on the right towards I 71 North: Columbus | 0.3 mi | |
| Merge left onto I 71 N | 64.0 mi | |
| Take exit 101 towards I 270: Dayton | 0.2 mi | |
| Keep right towards I 270 East: Wheeling | 0.8 mi | |
| Merge left onto Jack Nicklaus Freeway (I 270 E) | 11.2 mi | |
| Take the ramp towards I 70 West: Columbus | 0.2 mi | |
| Keep right towards I 70 East: Wheeling | 0.5 mi | |
| Merge left onto East Freeway (I 70) | 110.1 mi | |
| Keep right onto I 470 E | 10.8 mi | |
| Merge left onto I 70 | 26.5 mi | |
| Take the ramp towards I-79 north: Pittsburgh | 0.6 mi | |
| Continue onto I 79 N | 20.1 mi | |
| Take the ramp towards I 376 East: Pittsburgh | 0.5 mi | |
| Merge left onto Penn-Lincoln Parkway West (I 376 E) | 5.7 mi | |
| Keep right towards I 376 East: Monroeville | 0.5 mi | |
| Take exit 71A on the left towards Grant Street | 600 feet | |
| Continue left onto Grant Street | 0.2 mi | |
| You have arrived at your destination |
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Jackson, Tennessee - Pittsburgh, Pennsylvania