I 64 $east, I 79 $north
707.7 mi11 hours 21 mins
| Head southwest on US 127 Business | 0 feet | |
| Make a sharp left onto US 127 Business | 100 feet | |
| Enter the roundabout and take the 3rd exit onto US 127 Business | 100 feet | |
| Exit the roundabout onto US 127 Business | 4.8 mi | |
| Turn right onto Cumberland Parkway | 23.5 mi | |
| Take exit 86 towards KY 914: Somerset | 0.3 mi | |
| Continue onto KY 914 | 0.4 mi | |
| Turn left onto KY 80 | 11.1 mi | |
| Turn left onto KY 461 | 17.9 mi | |
| Continue onto Richmond Street (US 25) | 0.8 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 75 N | 32.2 mi | |
| Take the ramp towards KY 627: Boonesborough | 0.3 mi | |
| Turn right onto Boonesborough Road (KY 627) | 12.3 mi | |
| Continue onto Boone Avenue (KY 627) | 1.3 mi | |
| Turn left onto Maple Street (KY 627) | 1.3 mi | |
| Continue onto Paris Road (KY 627) | 0.2 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 64 E | 0.9 mi | |
| Keep left onto I 64 E | 152.2 mi | |
| Take the ramp on the left towards I 77 North: Parkersburg | 0.4 mi | |
| Merge right onto I 77 N | 1.5 mi | |
| Keep right towards I 79 North: Clarksburg | 148.0 mi | |
| Take the ramp towards I 68 East: Cumberland | 0.3 mi | |
| Continue onto I 68 E | 111.6 mi | |
| Keep right towards I 70 East: Hagerstown | 600 feet | |
| Keep left towards I 70 East: Hagerstown | 0.4 mi | |
| Merge left onto Dwight David Eisenhower Highway (I 70) | 600 feet | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 4.7 mi | |
| Continue onto I 70, US 40 (Dwight D Eisenhower Highway) (I 70) | 3.2 mi | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 16.2 mi | |
| Take the ramp towards I 81: Roanoke | 600 feet | |
| Keep left towards I 81 North: Harrisburg | 0.3 mi | |
| Keep right towards I 81 North: Hagerstown | 0.3 mi | |
| Keep left towards I 81 North: Harrisburg | 0.4 mi | |
| Merge left onto Maryland Veterans Memorial Highway (I 81 N) | 73.0 mi | |
| Continue onto George N Wade Bridge (I 81 N) | 1.0 mi | |
| Continue onto American Legion Memorial Highway (I 81 N) | 22.5 mi | |
| Keep right towards I 78 East: Allentown | 50.9 mi | |
| Keep right towards US 22 East: LVI Airport | 6.5 mi | |
| Take the ramp towards PA 145 | 800 feet | |
| Keep left towards PA 145 North: Whitehall | 200 feet | |
| Turn left onto MacArthur Road (PA 145 N) | 2.2 mi | |
| Turn right onto Lehigh Street | 1.2 mi | |
| Continue onto Eugene Street | 900 feet | |
| Continue onto Cypress Street | 400 feet | |
| Turn left onto 4th Street | 500 feet | |
| Continue right onto Main Street | 1.4 mi | |
| Turn right onto Laubach Avenue | 0.5 mi | |
| You have arrived at your destination |
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Jamestown, Kentucky - Northampton, Pennsylvania