US 69 $south, US 271
424.5 mi7 hours 30 mins
| Head south on South Main Street (MO 43) | 3.3 mi | |
| Make a slight right | 100 feet | |
| Take the ramp onto I 44 Bus | 800 feet | |
| Merge left onto I 44 W | 53.1 mi | |
| Take exit 283 towards US 69: Big Cabin | 0.4 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto US 69 S | 58.5 mi | |
| Continue onto South 32nd Street (US 64 E) | 69.1 mi | |
| Turn left | 0.3 mi | |
| Merge left onto Indian Nation Turnpike | 63.2 mi | |
| Continue onto Jake Pulliam Bypass (US 70) | 2.8 mi | |
| Take the ramp towards Hugo | 0.3 mi | |
| Keep right onto US 271 S | 22.6 mi | |
| Turn left onto US 271 | 400 feet | |
| Take the ramp on the left onto US 271 | 82.6 mi | |
| Turn left onto TX 300 | 11.6 mi | |
| Turn left onto FM 1844 | 4.9 mi | |
| Turn right onto US 259 (US 259 S) | 2.1 mi | |
| Continue onto North Eastman Road (US 259) | 1.1 mi | |
| Take the ramp towards Loop 281 | 800 feet | |
| Keep left towards Loop 281 | 700 feet | |
| Turn left onto East Loop 281 (Loop 281) | 5.5 mi | |
| Continue onto Southeast Loop 281 (Loop 281) | 1.7 mi | |
| Turn left onto FM 968 | 400 feet | |
| Take the ramp on the left towards I 20 | 0.2 mi | |
| Merge left onto I 20 | 17.6 mi | |
| Take the ramp towards US 59: Marshall | 0.3 mi | |
| Turn right onto East End Boulevard South (US 59) | 22.7 mi | |
| Turn right | 500 feet | |
| You have arrived at your destination |
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Joplin, Missouri - Carthage, Texas