Dwight D. Eisenhower Highway, I 70 $east; US 40 $east
327.1 mi4 hours 56 mins
| Head east | 200 feet | |
| Turn left onto North Webster Street | 1,000 feet | |
| Turn right onto West 6th Street | 2.1 mi | |
| Turn right onto J Hill Road | 800 feet | |
| Take the ramp on the left towards I-70 East: Topeka | 0.2 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 70) | 55.8 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 46.2 mi | |
| Take exit 148 towards US 54: Auxvasse | 0.2 mi | |
| Turn left onto US 54 E | 18.2 mi | |
| Turn right onto East Liberty Street (US 54) | 10.3 mi | |
| Turn left onto US 54 | 8.1 mi | |
| Turn right to stay on US 54 | 8.8 mi | |
| Turn right onto North Jefferson Street | 600 feet | |
| You have arrived at your destination, on the right |
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Junction City, KS, USA - Vandalia, MO, USA