I 70 $east; US 40 $east, I 55 $south
382.3 mi5 hours 46 mins
| Head east on Ann Avenue | 900 feet | |
| Turn left onto North 7th Street Trafficway (US 69 N) | 700 feet | |
| Turn right onto Minnesota Avenue | 0.4 mi | |
| Take the ramp towards I 70 East: Saint Louis | 0.2 mi | |
| Merge right onto Lewis and Clark Viaduct (I 70 E) | 1.1 mi | |
| Take exit 2A towards I 35 South: Wichita | 0.3 mi | |
| Merge left onto I 35 S | 0.5 mi | |
| Take the ramp on the left towards Saint Louis | 0.5 mi | |
| Merge left onto I 670 E | 0.5 mi | |
| Keep left towards I 70 East: Saint Louis | 0.4 mi | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 29.1 mi | |
| Continue onto I 70 E | 69.3 mi | |
| Keep left onto I 70 E | 108.5 mi | |
| Take exit 210A towards I 64 East: Chesterfield | 25.3 mi | |
| Take exit 25 towards I 270: Chicago | 0.3 mi | |
| Keep right towards I 270 South: Memphis | 0.3 mi | |
| Merge left onto I 270 S | 11.5 mi | |
| Take exit 1A towards I 55: Saint Louis | 0.4 mi | |
| Keep right towards I 55 South: Memphis | 0.4 mi | |
| Merge left onto I 55 S | 102.7 mi | |
| Keep left onto I 55 S | 26.5 mi | |
| Take the ramp towards US 62: Sikeston | 900 feet | |
| Keep left at the fork | 100 feet | |
| Turn left onto East Malone Avenue (US 62) | 3.2 mi | |
| Turn right onto North New Madrid Street | 600 feet | |
| Turn left onto West Center Street | 300 feet | |
| You have arrived at your destination, on the left |
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Kansas City, KS, USA - Sikeston, MO, USA