How to get from Key Largo, Florida to Sanibel, Florida

Discover, print or download the driving directions for the best route to go from Key Largo, Florida to Sanibel, Florida.

Enlarge the route map Key Largo, Florida - Sanibel, Florida

Driving directions from Key Largo, Florida to Sanibel, Florida

I 75 $north, Alligator Alley

204.0 mi3 hours 21 mins

Head southwest on Overseas Highway (US 1) 500 feet
Make a U-turn and continue on Overseas Highway (US 1) 2.5 mi
Continue onto Dixie Highway (US 1) 19.4 mi
Keep right onto Homestead Extension of Florida's Turnpike 17.3 mi
Keep left onto Homestead Extension of Florida's Turnpike 21.5 mi
Take the ramp towards I 75 North: Naples 1.1 mi
Merge left onto I 75 N 11.2 mi
Keep left towards Alligator Alley 109.6 mi
Take the ramp towards CR 840: San Carlos Park 0.4 mi
Keep right towards CR 840: San Carlos Park 0.6 mi
Go straight onto Alico Road (CR 840) 3.6 mi
Turn right onto South Tamiami Trail (US 41) 2.7 mi
Turn left onto Gladiolus Drive (CR 865) 1.5 mi
Turn left onto Summerlin Road (CR 869) 3.0 mi
Keep right onto Summerlin Road (CR 869) 2.8 mi
Turn right 700 feet
Turn left onto McGregor Boulevard (CR 867) 0.3 mi
Turn right to stay on McGregor Boulevard (CR 867) 2.1 mi
Continue onto Sanibel Causeway Boulevard (Span A) 2.8 mi
Continue onto Causeway Road 0.5 mi
Turn left onto Periwinkle Way 0.9 mi
You have arrived at your destination

Print directions
Key Largo, Florida - Sanibel, Florida

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.