How to get from Knoxville, Tennessee to Durham, North Carolina

Discover, print or download the driving directions for the best route to go from Knoxville, Tennessee to Durham, North Carolina.

Enlarge the route map Knoxville, Tennessee - Durham, North Carolina

Driving directions from Knoxville, Tennessee to Durham, North Carolina

I 40, I 40; I 85 $north

337.5 mi5 hours 26 mins

Head southeast on Henley Street (US 11) 200 feet
Make a U-turn and continue on Henley Street (US 11) 0.2 mi
Take the ramp on the right 0.3 mi
Keep right at the fork 0.5 mi
Merge left onto I 40 33.1 mi
Keep right towards I 40 East: Asheville 217.8 mi
Keep right onto I 40 31.8 mi
Merge right onto I 40 1.8 mi
Keep left onto I 40 36.7 mi
Keep left towards I 85 North: Durham 9.4 mi
Keep right towards NC 147 South: Downtown Durham 5.2 mi
Take the ramp towards Mangum Street 500 feet
Continue onto Morehead Avenue 900 feet
Turn left onto Roxboro Road (US 15 Business) 0.5 mi
Continue onto North Roxboro Street (US 15 Business) 300 feet
Turn right onto Holloway Street (US 70 Business) 100 feet
You have arrived at your destination

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Knoxville, Tennessee - Durham, North Carolina

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