I 41; US 41, US 141
275.0 mi5 hours 13 mins
| Head southeast on Main Street | 200 feet | |
| Turn left onto 4th Street North (US 53) | 0.4 mi | |
| Go straight onto 3rd Street North (US 53) | 500 feet | |
| Continue onto Copeland Avenue (US 53) | 0.4 mi | |
| Continue onto Rose Street (US 53) | 2.7 mi | |
| Take the ramp on the right onto US 53 N | 42.9 mi | |
| Continue onto I 90 | 22.9 mi | |
| Take exit 69 towards WI 82: Mauston | 0.2 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto State Highway 82 (WI 82) | 24.6 mi | |
| Continue onto East Ormsby Street (WI 82) | 1.1 mi | |
| Continue onto State Highway 82 (WI 82) | 3.5 mi | |
| Continue onto State Highway 23 (WI 23) | 6.1 mi | |
| Continue onto Underwood Avenue (WI 23) | 1.8 mi | |
| Turn left onto West Montello Street (WI 23) | 700 feet | |
| Continue onto State Highway 23 (WI 22) | 10.5 mi | |
| Continue onto South 2nd Street | 0.5 mi | |
| Turn right onto West Main Street (WI 23) | 0.8 mi | |
| Turn right onto South Fulton Street (WI 23) | 0.8 mi | |
| Continue onto State Highway 23 (WI 23) | 13.0 mi | |
| Continue onto West Fond du Lac Street (WI 23 S) | 1.3 mi | |
| Turn left onto North Union Street (CTH FF) | 400 feet | |
| Go straight onto West Oshkosh Street | 1.4 mi | |
| Continue onto State Highway 44 (WI 44) | 15.8 mi | |
| Turn left towards I-41_North: Appleton | 0.2 mi | |
| Merge left towards Appleton | 70.4 mi | |
| Keep left towards US 141: Crivitz | 52.3 mi | |
| Turn left onto Coleman Avenue | 0.4 mi | |
| Turn left onto Grant Street | 800 feet | |
| Turn right onto County Road V (CTH V) | 0.4 mi | |
| You have arrived at your destination |
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La Crosse, Wisconsin - Amberg, Wisconsin