Indiana Toll Road, Ohio Turnpike
1,119.1 mi17 hours 21 mins
| Head southeast on Main Street | 200 feet | |
| Turn left onto 4th Street North (US 53) | 0.4 mi | |
| Go straight onto 3rd Street North (US 53) | 500 feet | |
| Continue onto Copeland Avenue (US 53) | 0.4 mi | |
| Continue onto Rose Street (US 53) | 2.7 mi | |
| Take the ramp on the right onto US 53 N | 42.9 mi | |
| Continue onto I 90 | 97.1 mi | |
| Continue towards I 39:I 90: Chicago | 81.5 mi | |
| Keep left onto Jane Addams Memorial Tollway (I 90) | 40.5 mi | |
| Keep left onto Jane Addams Memorial Tollway (I 90 E) | 1.0 mi | |
| Merge right onto Kennedy Expressway (I 90) | 5.6 mi | |
| Keep right onto Kennedy Expressway (I 90) | 8.3 mi | |
| Continue onto Dan Ryan Expressway (I 90) | 2.4 mi | |
| Keep left towards I 90 Express | 3.8 mi | |
| Take the ramp towards I 90 East: Chicago Skyway | 0.4 mi | |
| Merge right onto Dan Ryan Expressway (I 90) | 0.5 mi | |
| Keep left towards I 90 East: Chicago Skyway | 10.6 mi | |
| Keep left onto Indiana Toll Road (I 90) | 153.6 mi | |
| Continue onto Ohio Turnpike (I 80 E) | 141.5 mi | |
| Keep left onto Ohio Turnpike (I 80 E) | 9.2 mi | |
| Keep right onto I 480 E | 26.3 mi | |
| Keep right onto Outerbelt South Freeway (I 480 E) | 2.5 mi | |
| Merge left onto Outerbelt East Freeway (I 271 S) | 3.0 mi | |
| Keep right towards I 480: Youngstown | 10.6 mi | |
| Take the ramp towards Youngstown | 0.5 mi | |
| Keep right towards Youngstown | 1,000 feet | |
| Merge left onto Ohio Turnpike (I 80 E) | 53.8 mi | |
| Continue onto Pennsylvania Turnpike (I 76 E) | 1.2 mi | |
| Keep left towards E-ZPass Express | 29.6 mi | |
| Keep right onto Pennsylvania Turnpike (I 76 E) | 130.8 mi | |
| Take the ramp towards US 30: Breezewood | 1.9 mi | |
| Keep left towards US 30 West: Breezewood | 0.7 mi | |
| Turn left towards I 70 East: Baltimore | 75.9 mi | |
| Take the ramp towards Washington | 0.4 mi | |
| Continue onto Eisenhower Memorial Highway (I 270 N) | 22.9 mi | |
| Keep right onto I 270 S | 0.3 mi | |
| Continue onto I 270 N | 6.4 mi | |
| Keep right towards I 270 Spur: Washington | 2.0 mi | |
| Merge right onto Capital Beltway (I 495 W) | 1.2 mi | |
| Keep left onto Capital Beltway (I 495 W) | 4.7 mi | |
| Keep right onto Capital Beltway (I 495 S) | 11.3 mi | |
| Take the ramp towards I 95 South: Richmond | 0.5 mi | |
| Keep left at the fork | 0.3 mi | |
| Keep left towards I 95 South: Richmond | 0.4 mi | |
| Merge left onto Henry G. Shirley Memorial Highway (I 395 S) | 36.6 mi | |
| Take the ramp towards US 17 Business: Falmouth | 0.3 mi | |
| Merge left onto Warrenton Road (US 17 Business) | 1.8 mi | |
| Turn right onto Cambridge Street (US 1) | 0.4 mi | |
| Continue onto Jefferson Davis Highway (US 1) | 400 feet | |
| Turn left onto Princess Anne Street (US 1 Business) | 1.6 mi | |
| Turn right onto Lafayette Boulevard (US 1 Business) | 300 feet | |
| Turn left onto Charles Street (US 17 Business) | 0.2 mi | |
| Continue slightly right onto Dixon Street (US 17 Business) | 0.8 mi | |
| Continue onto Tidewater Trail (US 17 Business) | 4.6 mi | |
| Make a sharp left onto Mills Drive (US 17) | 1.6 mi | |
| Continue onto Tidewater Trail (US 17) | 38.4 mi | |
| Continue onto Church Lane (US 17) | 0.7 mi | |
| Continue onto Tappahannock Boulevard (US 17) | 2.3 mi | |
| Keep left onto US 17 | 800 feet | |
| Take the ramp onto US 17 | 39.5 mi | |
| Turn left onto Farys Mill Road (SR 606) | 300 feet | |
| You have arrived at your destination |
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La Crosse, Wisconsin - Ark, Virginia